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Titolo:
DIFFERENTIAL-EFFECTS OF POTASSIUM CHANNEL BLOCKERS ON EXTRACELLULAR CONCENTRATIONS OF DOPAMINE AND 5-HT IN THE STRIATUM OF CONSCIOUS RATS
Autore:
DAWSON LA; ROUTLEDGE C;
Indirizzi:
WYETH AYERST RES,CN8000 PRINCETON NJ 08543 WYETH RES UK,DEPT NEUROPHARMACOL MAIDENHEAD SL6 0PH BERKS ENGLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 8, volume: 116, anno: 1995,
pagine: 3260 - 3264
SICI:
0007-1188(1995)116:8<3260:DOPCBO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE-RELEASE; CEREBRAL-CORTEX; K+ CHANNEL; 4-AMINOPYRIDINE; HIPPOCAMPUS; APAMIN; TOXINS; DENDROTOXIN; NUCLEUS; VENOM;
Keywords:
POTASSIUM CHANNEL BLOCKER; DOPAMINE; 5-HT AND MICRODIALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
L.A. Dawson e C. Routledge, "DIFFERENTIAL-EFFECTS OF POTASSIUM CHANNEL BLOCKERS ON EXTRACELLULAR CONCENTRATIONS OF DOPAMINE AND 5-HT IN THE STRIATUM OF CONSCIOUS RATS", British Journal of Pharmacology, 116(8), 1995, pp. 3260-3264

Abstract

1 The selective Ca2+-activated K+ channel blocker apamin increased extracellular 5-hydroxytryptamine (5-HT) concentrations in the striatum when administered through the microdialysis probe at doses of 0.1 mM and 1 mM. Extracellular dopamine concentrations increased only at the highest dose administered (1 mM). 2 Mast cell degranulating peptide (MCDP), which blocks the dendrotoxin sensitive delayed rectifier (DR) current, increased extracellular concentrations of dopamine at doses of 10 mu M-100 mu M but had no effect on 5-HT. 3 The non selective K+ channel blocker tetraethylammonium (TEA) induced a dose-dependent (1 mM-10mM) increase in extracellular dopamine concentrations and an increasein 5-HT which showed little or no dose-dependency. 4 4-Aminopyridine (4-AP), a blocker with some similar characteristics to MCDP, increasedextracellular dopamine concentrations at doses of 10 mu M-1 mM, but had no effect on 5-HT. 5 These findings suggest that dopamine release may be modulated by DR-like current and/or A-current K+ channels. However, in view of the similar effects of MCDP and 4-AP at the concentrations used it is more likely that the dendrotoxin-sensitive DR-like current is involved. In contrast, 5-HT release appears to be modulated by Ca2+-activated K+ channels.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 08:38:40