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Titolo:
POSSIBLE INHIBITORY EFFECTS OF PROMOTION STAGE TREATMENT WITH THYMOSIN FRACTION-5 ON N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE-INITIATED URINARY-TRACT CARCINOGENESIS IN NON SHI MICE/
Autore:
MURAI T; MORI S; HATO F; KINOSHITA Y; FUKUSHIMA S;
Indirizzi:
OSAKA CITY UNIV,SCH MED,DEPT PATHOL 1,ABENO KU,1-4-54 ASAHI MACHI OSAKA 545 JAPAN OSAKA CITY UNIV,SCH MED,DEPT PHYSIOL 2,ABENO KU OSAKA 545 JAPAN SHIONOGI & CO LTD,SHIONOGI RES LABS,ABURAHI LABS SHIGA 52034 JAPAN
Titolo Testata:
International journal of oncology
fascicolo: 1, volume: 8, anno: 1996,
pagine: 117 - 124
SICI:
1019-6439(1996)8:1<117:PIEOPS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLADDER-TUMOR INDUCTION; RENAL PELVIC CARCINOMA; RATS; THYMOCYTES; REDUCTION; INVITRO; RESPONSIVENESS; LYMPHOCYTES; CANCERS; THYMUS;
Keywords:
THYMOSIN FRACTION 5; URINARY TRACT CARCINOGENESIS; NON/SHI MICE; N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
T. Murai et al., "POSSIBLE INHIBITORY EFFECTS OF PROMOTION STAGE TREATMENT WITH THYMOSIN FRACTION-5 ON N-BUTYL-N-(4-HYDROXYBUTYL)NITROSAMINE-INITIATED URINARY-TRACT CARCINOGENESIS IN NON SHI MICE/", International journal of oncology, 8(1), 1996, pp. 117-124

Abstract

The modifying effects of thymosin fraction 5 (TF5), a dialyzable glycoprotein extract obtained from calf thymus, on second stage urinary tract carcinogenesis after N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) initiation were investigated in NON/Shi male mice. BBN was administeredfor 8 weeks and then TF5 was administered subcutaneously twice a weekfor 12 weeks. The incidence of urinary bladder carcinomas was decreased in the TF5 treatment group, but the malignancy of the renal pelvic carcinomas appeared to be enhanced. We repeated the experiment to obtain confirmatory evidence, but found no significant effect, although TF5 did stimulate the immune surveillance system. The reason why this discrepancy occurred might be related to the degree of hydronephrosis orthe confounding influence of renal pelvic carcinomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 19:02:21