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Titolo:
HLA DRB1(ASTERISK)DQB1(ASTERISK) HAPLOTYPE IN HTLV-I-ASSOCIATED FAMILIAL INFECTIVE DERMATITIS MAY PREDICT DEVELOPMENT OF HTLV-I-ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS
Autore:
LAGRENADE L; SONODA S; MILLER W; PATE E; RODGERSJOHNSON P; HANCHARD B; CRANSTON B; FUJIYOSHI T; YASHIKI S; BLANK M; GIBBS CJ; MANNS A;
Indirizzi:
UNIV W INDIES,DEPT MED,KINGSTON 7 MONA JAMAICA UNIV W INDIES,DEPT CHILD HLTH MONA JAMAICA UNIV W INDIES,DEPT PATHOL MONA JAMAICA KAGOSHIMA UNIV,DEPT VIROL KAGOSHIMA 890 JAPAN NCI,NATL INST NEUROL DISORDERS & STROKE,CENT NERVOUS SYST STUDIES LABBETHESDA MD 20892 NCI,VIRAL EPIDEMIOL BRANCH BETHESDA MD 00000
Titolo Testata:
American journal of medical genetics
fascicolo: 1, volume: 61, anno: 1996,
pagine: 37 - 41
SICI:
0148-7299(1996)61:1<37:HDHIHF>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL LEUKEMIA; VIRUS TYPE-I; ANTIBODIES; CARRIERS;
Keywords:
HLA; DRB1; DQB1; HTLV-I; INFECTIVE DERMATITIS; HTLV-I-ASSOCIATED MYELOPATHY; TROPICAL SPASTIC PARAPARESIS; JAMAICA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
L. Lagrenade et al., "HLA DRB1(ASTERISK)DQB1(ASTERISK) HAPLOTYPE IN HTLV-I-ASSOCIATED FAMILIAL INFECTIVE DERMATITIS MAY PREDICT DEVELOPMENT OF HTLV-I-ASSOCIATED MYELOPATHY TROPICAL SPASTIC PARAPARESIS", American journal of medical genetics, 61(1), 1996, pp. 37-41

Abstract

A possible causal association between infective dermatitis and HTLV-Iinfection was reported in 1990 and confirmed in 1992, We now report familial infective dermatitis (ID) occurring in a 28-year-old mother and her 9-year-old son, The mother was first diagnosed with ID in 1969 at the age of 2 years in the Dermatology Unit at the University Hospital of the West Indies (U.H.W.I.) in Jamaica. The elder of her 2 sons was diagnosed with ID at the age of 3 years, also at U.H.W.I, Both mother and son are HTLV-I-seropositive. A second, younger son, currently age 2 years, is also HTLV-I-seropositive, but without clinical evidence of ID, Major histocompatibility complex (MHC), class II, human leucocyte antigen (HLA) genotyping documented a shared class II haplotype, DRB1DQB1* (1101-0301), in the mother and her 2 sons, This same haplotype has been described among Japanese patients with HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and has been associated with a possible pathologically heightened immune response to HTLV-Iinfection, The presence of this haplotype in these familial ID cases with clinical signs of HAM/TSP may have contributed to their risk for development of HAM/TSP, The unaffected, HTLV-I-seropositive, younger son requires close clinical follow-up. (C) 1996 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 18:38:42