Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PLATELETS IN FIBRINOLYTIC SYSTEM
Autore:
KORBUT R; GRYGLEWSKI RJ;
Indirizzi:
JAGIELLONIAN UNIV,COLL MED,DEPT PHARMACOL,16 GRZEGORZECKA PL-31531 KRAKOW POLAND
Titolo Testata:
Journal of Physiology and Pharmacology
fascicolo: 4, volume: 46, anno: 1995,
pagine: 409 - 418
SICI:
0867-5910(1995)46:4<409:PIFS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR; STREPTOKINASE-INDUCED THROMBOLYSIS; TISSUE-TYPE; CORONARY THROMBOLYSIS; SODIUM-NITROPRUSSIDE; NITRIC-OXIDE; PROSTACYCLIN; REOCCLUSION; THROMBOSIS; THROMBOXANE-A2;
Keywords:
PLATELETS; FIBRINOLYSIS; PAI-1; STREPTOKINASE; T-PA; PLASMIN; PROSTACYCLIN; ASPIRIN; THROMBOXANE; A(2)-INHIBITORS; CAMP; C-GMP;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
R. Korbut e R.J. Gryglewski, "PLATELETS IN FIBRINOLYTIC SYSTEM", Journal of Physiology and Pharmacology, 46(4), 1995, pp. 409-418

Abstract

Platelets play a vital role in mediating the activity of plasma fibrinolytic system. They have both the potential to inhibit as wellasto activate fibrinolysis. Just as platelet can affect thrombolysis, thrombolytic agents can have reciprocal effects on platelet function. Accumulating evidence indicates that thrombolysis induced both by streptokinase and t-PA results in rapid activation of platelets, the phenomenon being possibly responsible for reocclusion of arteries after successfulthrombolysis. However, caution is required in comparing the results of the various studies because of differences in the thrombotic models employed, with the major variables being the mechanism of thrombus formation (in vivo or in in vitro), the platelet concentrations and the doses of investigated agent. Various studies indicate that adjunctive therapy with anti-platelet agents, such as inhibitors of cyclooxygenase, inhibitors of thromboxane A(2)-synthase and activators of platelet cyclic-AMP or -GMP may lower the dose of the thrombolytic agent required to attain reperfusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:33:06