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Titolo:
A-FACTOR AND STREPTOMYCIN BIOSYNTHESIS IN STREPTOMYCES-GRISEUS
Autore:
HORINOUCHI S; BEPPU T;
Indirizzi:
UNIV TOKYO,DEPT AGR CHEM,BUNKYO KU,YAYOI 1-1-1 TOKYO 113 JAPAN
Titolo Testata:
Antonie van Leeuwenhoek
fascicolo: 2, volume: 64, anno: 1993,
pagine: 177 - 186
SICI:
0003-6072(1993)64:2<177:AASBIS>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
2-COMPONENT REGULATORY SYSTEM; VIRGINIAE BUTANOLIDE-C; SECONDARY METABOLISM; GENE-CLUSTER; ANTHRACYCLINE BIOSYNTHESIS; ANTIBIOTIC BIOSYNTHESIS; AUTOREGULATORY FACTORS; COELICOLOR LOCUS; BINDING-PROTEIN; IDENTIFICATION;
Keywords:
A-FACTOR; A-FACTOR RECEPTOR PROTEIN; SIGNAL TRANSDUCTION; STREPTOMYCES GRISEUS; STREPTOMYCIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
S. Horinouchi e T. Beppu, "A-FACTOR AND STREPTOMYCIN BIOSYNTHESIS IN STREPTOMYCES-GRISEUS", Antonie van Leeuwenhoek, 64(2), 1993, pp. 177-186

Abstract

Accumulating data have shown that the metabolites with a gamma-butyrolactone ring functions as an autoregulatory factor or a microbial hormone for the expression of various phenotypes not only in a variety of Streptomyces spp, but also in the distantly related bacteria. A-factor, as a representative of this type of autoregulators, triggers streptomycin biosynthesis and cellular differentiation in Streptomyces griseus. A model for the A-factor regulatory cascade on the basis of recent work is as follows. At an early step in the A-factor regulatory relay,the positive A-factor signal is first received by an A-factor receptor protein that is comparable in every aspect to eukaryotic hormone receptors, and then, via one or more regulatory steps, transmitted to an A-factor-responsive protein that binds to the upstream activation sequence of the strR gene, a regulatory gene in the streptomycin biosynthetic gene cluster. The StrR protein thus induced appears to activate the other streptomycin biosynthetic genes. This review summarizes the characteristics of A-factor as a microbial hormone and the A-factor regulatory relay leading to streptomycin production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 15:52:36