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Titolo:
EXPRESSION OF CD44V6 IS ASSOCIATED WITH CELLULAR DYSPLASIA IN COLORECTAL EPITHELIAL-CELLS
Autore:
ORZECHOWSKI HD; BECKENBACH C; HERBST H; STOLZEL U; RIECKEN EO; STALLMACH A;
Indirizzi:
UNIV SAARLAND,MED KLIN 2 D-66421 HOMBURG GERMANY FREE UNIV BERLIN,BENJAMIN FRANKLIN KLINIKUM,DEPT MED W-1000 BERLIN GERMANY INST PATHOL BERLIN GERMANY
Titolo Testata:
European journal of cancer
fascicolo: 12, volume: 31A, anno: 1995,
pagine: 2073 - 2079
SICI:
0959-8049(1995)31A:12<2073:EOCIAW>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMING RECEPTOR CD44; INTEGRIN ADHESION MOLECULES; LAMININ RECEPTOR; HUMAN COLON; VARIANT; CANCER; GENE; TRANSFORMATION; PROGRESSION; ISOFORMS;
Keywords:
CD44 VARIANTS; COLORECTAL CARCINOMA; IN SITU HYBRIDIZATION; MALIGNANT TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
H.D. Orzechowski et al., "EXPRESSION OF CD44V6 IS ASSOCIATED WITH CELLULAR DYSPLASIA IN COLORECTAL EPITHELIAL-CELLS", European journal of cancer, 31A(12), 1995, pp. 2073-2079

Abstract

There is increasing evidence that the expression of variants of the glycoprotein CD44 is related to the invasive and metastatic potential of tumour cells. By in situ hybridisation, we analysed the cellular expression of human homologues of a rat metastasis-associated CD44 variant v6 in invasive and non-invasive colorectal neoplasia and normal colonic mucosa. No specific hybridisation signals could be detected in epithelial cells of the normal crypt (n = 10). In contrast, we found moderate epithelial hybridisation signals in adenomatous polyps of mild dysplasia (n = 6). Adenoma cells of moderate or severe dysplasia (n = 7)showed increased hybridisation signals compared to mildly dysplastic adenomas (P less than or equal to 0.01). We could not demonstrate significant differences in CD44v6 transcript levels between cells of dysplastic adenoma and primary adenocarcinoma (n = 11) (P greater than or equal to 0.05). Furthermore, we were not able to demonstrate a significant difference between primary and metastatic tumours (n = 7) (P greater than or equal to 0.05). However, there was a significant differencebetween metastatic carcinoma and adenomas with advanced dysplasia (P less than or equal to 0.01). Our data demonstrate that significant transcriptional expression of CD44v6 is not confined to invasive tumour cells, but is already detectable in cells of adenomatous polyps showingmild dysplasia. The results of this study show a close relationship between cellular dysplasia and steady state levels of CD44 variant v6 transcripts in colorectal neoplasms.

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Documento generato il 05/12/20 alle ore 10:34:02