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Titolo:
BRAIN DOPAMINE RESPONSE IN ISOLATED 10-DAY-OLD RATS - ASSESSMENT USING D-2 BINDING AND DOPAMINE TURNOVER
Autore:
KEHOE P; CLASH K; SKIPSEY K; SHOEMAKER WJ;
Indirizzi:
TRINITY COLL,DEPT PSYCHOL HARTFORD CT 06106 UNIV CONNECTICUT,CTR HLTH,DEPT PSYCHIAT FARMINGTON CT 06030
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 1, volume: 53, anno: 1996,
pagine: 41 - 49
SICI:
0091-3057(1996)53:1<41:BDRII1>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
3,4-DIHYDROXYPHENYLACETIC ACID DOPAC; NORADRENALINE TURNOVER; INVIVO MICRODIALYSIS; MATERNAL SEPARATION; CEREBRAL-CORTEX; H-3 RACLOPRIDE; STRESS; RELEASE; RECEPTORS; NOREPINEPHRINE;
Keywords:
DOPAMINE; RAT PUP; ISOLATION; IN VIVO BINDING; EX VIVO BINDING; IN VITRO BINDING; DOPAC; TURNOVER; STRESS; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
P. Kehoe et al., "BRAIN DOPAMINE RESPONSE IN ISOLATED 10-DAY-OLD RATS - ASSESSMENT USING D-2 BINDING AND DOPAMINE TURNOVER", Pharmacology, biochemistry and behavior, 53(1), 1996, pp. 41-49

Abstract

A single 5-min isolation from the nest, dam, and siblings in 10-day-old rat pups was investigated for its effect on brain dopamine systems. The release of dopamine in innervated brain regions was measured in separate studies using in vivo ligand binding of H-3-raclopride, ex vivo binding using H-3-raclopride, and neurochemical measurement of the dopamine turnover using levels of DOPAC and dopamine. In addition, in vitro homogenate binding was performed to determine baseline B-max and K-d values for 3H-raclopride binding sites across treatments. Isolation for 5 min in a ''novel'' environment resulted in decreased H-3-raclopride binding in striatum and septum as determined by both in vivo andex vivo binding, as well as increased dopamine turnover. There was nodifference in B-max and K-d values for H-3-raclopride in these brain regions after the 5-min isolation, indicating that the binding decreases were due to an increase of available dopamine, presumably from terminal release. The convergence of results from three different techniques supports the interpretation that dopamine is released during the 5-min isolation in both brain regions.

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Documento generato il 18/01/20 alle ore 10:44:08