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Titolo:
THE ROLE OF MESOLIMBIC DOPAMINERGIC AND RETROHIPPOCAMPAL AFFERENTS TOTHE NUCLEUS-ACCUMBENS IN LATENT INHIBITION - IMPLICATIONS FOR SCHIZOPHRENIA
Autore:
GRAY JA; JOSEPH MH; HEMSLEY DR; YOUNG AMJ; WARBURTON EC; BOULENGUEZ P; GRIGORYAN GA; PETERS SL; RAWLINS JNP; TAIB CT; YEE BK; CASSADAY H; WEINER I; GAL G; GUSAK O; JOEL D; SHADACH E; SHALEV U; TARRASCH R; FELDON J;
Indirizzi:
INST PSYCHIAT,DEPT PSYCHOL,DE CRESPIGNY PK LONDON SE5 8A ENGLAND INST PSYCHIAT,MRC,BEHAV NEUROCHEM GRP LONDON SE5 8A ENGLAND UNIV OXFORD,DEPT EXPTL PSYCHOL OXFORD OX2 3UD ENGLAND TEL AVIV UNIV,DEPT PSYCHOL,LAB BEHAV NEUROSCI IL-6997 TEL AVIV ISRAEL
Titolo Testata:
Behavioural brain research
fascicolo: 1-2, volume: 71, anno: 1995,
pagine: 19 - 31
SICI:
0166-4328(1995)71:1-2<19:TROMDA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC AMPHETAMINE; SYSTEMIC AMPHETAMINE; CONDITIONING RATHER; ATTENTION DISORDER; CAUDATE-PUTAMEN; HALOPERIDOL; RATS; PREEXPOSURE; ABOLITION; LESIONS;
Keywords:
SCHIZOPHRENIA; LATENT INHIBITION; NUCLEUS ACCUMBENS; HIPPOCAMPAL FORMATION; MESOLIMBIC DOPAMINE SYSTEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
81
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Gray et al., "THE ROLE OF MESOLIMBIC DOPAMINERGIC AND RETROHIPPOCAMPAL AFFERENTS TOTHE NUCLEUS-ACCUMBENS IN LATENT INHIBITION - IMPLICATIONS FOR SCHIZOPHRENIA", Behavioural brain research, 71(1-2), 1995, pp. 19-31

Abstract

Latent inhibition (LI) consists in a retardation of conditioning seenwhen the to-be-conditioned stimulus is first presented a number of times without other consequence. Disruption of LI has been proposed as apossible model of the cognitive abnormality that underlies the positive psychotic symptoms of acute schizophrenia. We review here evidence in support of the model, including experiments tending to show that: (1) disruption of LI is characteristic of acute, positively-symptomaticschizophrenia; (2) LI depends upon dopaminergic activity; (3) LI depends specifically upon dopamine release in n. accumbens; (4) LI dependsupon the integrity of the hippocampal formation and the retrohippocampal region reciprocally connected to the hippocampal formation; (5) the roles of n. accumbens and the hippocampal system in LI are interconnected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:12:06