Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
APOLIPOPROTEIN-E, SYNAPTIC PLASTICITY AND ALZHEIMERS-DISEASE
Autore:
POIRIER J; MINNICH A; DAVIGNON J;
Indirizzi:
UNIV MONTREAL,CLIN RES INST MONTREAL,HYPERLIPIDEMIA & ATHEROSCLEROSISRES GRP,110 PINE AVE W MONTREAL PQ H2W 1R7 CANADA UNIV MONTREAL,CLIN RES INST MONTREAL,HYPERLIPIDEMIA & ATHEROSCLEROSISRES GRP MONTREAL PQ H2W 1R7 CANADA MCGILL UNIV,DOUGLAS HOSP,RES CTR MONTREAL PQ CANADA MCGILL UNIV,DEPT PSYCHIAT MONTREAL PQ CANADA
Titolo Testata:
Annals of medicine
fascicolo: 6, volume: 27, anno: 1995,
pagine: 663 - 670
SICI:
0785-3890(1995)27:6<663:ASPAA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEIN; CYSTEINE-ARGININE INTERCHANGE; HUMAN-PLASMA-LIPOPROTEINS; DENTATE GYRUS; SENILE DEMENTIA; E POLYMORPHISM; ADULT RAT; CHOLINE-ACETYLTRANSFERASE; CHOLESTEROL-SYNTHESIS; HIPPOCAMPAL-FORMATION;
Keywords:
APOLIPOPROTEIN E; ALZHEIMERS DISEASE; BRAIN; LIPID; HUMAN; LDL RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
89
Recensione:
Indirizzi per estratti:
Citazione:
J. Poirier et al., "APOLIPOPROTEIN-E, SYNAPTIC PLASTICITY AND ALZHEIMERS-DISEASE", Annals of medicine, 27(6), 1995, pp. 663-670

Abstract

Apolipoprotein E (apoE) has been studied extensively with regard to its role in plasma lipoprotein lipid transport, A role for apoE in the transport of membrane cholesterol and phospholipid In the central and peripheral nervous system has also been studied. Entorhinal cortex-lesioned rats have been used extensively to examine the molecular mechanisms associated with deafferentation and reinnervation in the CNS; studies of the role of apoE in this process using this animal model are described, In all human populations examined, three common apoE isoforms, apoE2, apoE3 and apoE4, result from multiple alleles epsilon 2, epsilon 3 and epsilon 4 at a single apoE genetic locus, These isoforms impart well-characterized functional differences in plasma lipoprotein transport, which are reviewed herein. Also discussed are less well-studied possible apoE-isoform specific differences in central nervous system function, These are currently of critical importance due to numerousrecent studies showing an association of epsilon 4 with increased risk for Alzheimer's disease, Diverse hypotheses as to the molecular basis for this association, as well as the supporting experimental evidence, are reviewed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:25:39