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Titolo:
ASPIRIN AND ACETAMINOPHEN REDUCED BOTH FOS EXPRESSION IN RAT LUMBAR SPINAL-CORD AND INFLAMMATORY SIGNS PRODUCED BY CARRAGEENAN INFLAMMATION
Autore:
HONORE P; BURITOVA J; BESSON JM;
Indirizzi:
INSERM,U161,2 RUE ALESIA F-75014 PARIS FRANCE EPHE F-75014 PARIS FRANCE
Titolo Testata:
Pain
fascicolo: 3, volume: 63, anno: 1995,
pagine: 365 - 375
SICI:
0304-3959(1995)63:3<365:AAARBF>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-LIKE IMMUNOREACTIVITY; C-FOS; DORSAL HORN; LYSINE-ACETYLSALICYLATE; THALAMIC NEURONS; ARTHRITIC RATS; PARACETAMOL; STIMULATION; DRUGS; MORPHINE;
Keywords:
ACETAMINOPHEN; ASPIRIN; CARRAGEENAN INFLAMMATION; C-FOS; IMMEDIATE EARLY GENE; SPINAL CORD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
72
Recensione:
Indirizzi per estratti:
Citazione:
P. Honore et al., "ASPIRIN AND ACETAMINOPHEN REDUCED BOTH FOS EXPRESSION IN RAT LUMBAR SPINAL-CORD AND INFLAMMATORY SIGNS PRODUCED BY CARRAGEENAN INFLAMMATION", Pain, 63(3), 1995, pp. 365-375

Abstract

This study, performed in freely moving rats, evaluates the effects ofthe two most prescribed analgesics, aspirin and acetaminophen, on carrageenin inflammation and the associated c-Fos expression in the rat lumbar spinal cord. Maximal dorsal horn c-Fos expression is observed 3 h after carrageenin (6 mg/150 mu l of saline), with Fos-like (Fos-LI) neurones being predominantly located in laminae I-II and V-VI (41 +/- 3% and 39 +/- 5% of the total number of Fos-LI neurones per section for the control group, respectively) of the dorsal horn. Pretreatment with aspirin (75 or 150 mg/kg, i.v.) reduced the number of Fos-LI neurones induced by carrageenin-inflammation (28 +/- 2% and 45 +/- 1% reduction, respectively; P < 0.001 for both). Acetaminophen (75 or 150 mg/kg, i.v.) reduced the number of Fos-LI neurones (19 +/- 1% and 43 +/- 1%reduction, respectively; P < 0.001 for both). When considering the lower dose (75 mg/kg), the effects of aspirin were significantly more marked than those of acetaminophen (P < 0.001). There was a tendency forboth aspirin and acetaminophen to have a more pronounced effect on the number of Fos-LI neurones located in deeper laminae, these differential effects being significant for 75 mg/kg of aspirin (P < 0.01) and 150 mg/kg of acetaminophen (P < 0.01). Both the two doses of aspirin and acetaminophen greatly reduced the inflammatory signs associated withthe intraplantar injection of carrageenin. Furthermore there was a positive correlation between the effects of aspirin and acetaminophen onthe number of Fos-LI neurones and the inflammatory signs which developed after carrageenin. Our results suggest that the effects of both drugs are mainly due to a peripheral site of action without rejecting anadditional central site of action of systemic non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen. In addition, our results suggest that the approach we used could be a useful tool to evaluate systematically and quantitatively the effects of NSAIDs. Finally, the effects obtained with the low dose of acetaminophen question the classical view of textbooks claiming that such a compound had no anti-inflammatory effect and are in agreement with previous observations in humans (Skjelbred and Lokken 1979; Skjelbred et al. 1984).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 00:05:17