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Titolo:
MOLECULAR MODELING OF SINGLET-OXYGEN BINDING TO ANTHRAQUINONES IN RELATION TO THE PEROXIDATING ACTIVITY OF ANTITUMOR ANTHRAQUINONE DRUGS
Autore:
LIWO A; JEZIOREK D; OSSOWSKI T; DYL D; TEMPCZYK A; TARASIUK J; NOWACKA M; BOROWSKI E; WOZNICKI W;
Indirizzi:
UNIV GDANSK,DEPT CHEM,J SOBIESKIEGO 18 PL-80952 GDANSK POLAND NICHOLAS COPERNICUS UNIV,INST PHYS PL-87100 TORUN POLAND AGOURON PHARMACEUT INC LA JOLLA CA 92037 GDANSK TECH UNIV,DEPT PHARMACEUT TECHNOL & BIOCHEM PL-80952 GDANSK POLAND
Titolo Testata:
Acta Biochimica Polonica
fascicolo: 4, volume: 42, anno: 1995,
pagine: 445 - 456
SICI:
0001-527X(1995)42:4<445:MMOSBT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
REDOX CYCLING ACTIVITY; ANTI-CANCER AGENTS; NADH DEHYDROGENASE; CARDIAC MITOCHONDRIA; RADICAL FORMATION; SUPEROXIDE ANION; PRIMARY PRODUCT; MECHANISM; ANTHRACYCLINES; ANTIBIOTICS;
Keywords:
ANTHRACYCLINE ANTICANCER DRUGS; PEROXIDATION; OXYGEN ADDITION TO AROMATIC COMPOUNDS; CYCLIC VOLTAMMETRY; QUANTUM MECHANICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
A. Liwo et al., "MOLECULAR MODELING OF SINGLET-OXYGEN BINDING TO ANTHRAQUINONES IN RELATION TO THE PEROXIDATING ACTIVITY OF ANTITUMOR ANTHRAQUINONE DRUGS", Acta Biochimica Polonica, 42(4), 1995, pp. 445-456

Abstract

Anthraquinone derivatives are important anti-cancer drugs possessing,however, undesirable peroxidating and, in consequence, cardiotoxic properties. This results from the mediation by these compounds of the one-electron reduction processes of the oxygen molecule, which produces the highly toxic superoxide anion radical and other active oxygen species. This article summarizes the results of our studies on the molecular aspects of the mechanism of anthraquinone-mediated peroxidation which were carried out using enzymatic-assay, electrochemical, and quantum-mechanical methods.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/10/20 alle ore 23:32:10