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Titolo:
LACK OF EFFICACY OF INTERFERON-ALPHA THERAPY IN RECURRENT, ADVANCED CERVICAL-CANCER
Autore:
WADLER S; BURK RD; NEUBERG D; RAMEAU R; RUNOWICZ CD; GOLDBERG G; MCGILL F; TACHEZY R; COMIS R; EDMONSON J; WIERNIK PH;
Indirizzi:
MONTEFIORE MED CTR,DEPT ONCOL BRONX NY 10467 ALBERT EINSTEIN COLL MED,DEPT OBSTET & GYNECOL BRONX NY 10467 ALBERT EINSTEIN COLL MED,DEPT MICROBIOL & IMMUNOL BRONX NY 10467 DANA FARBER CANC INST BOSTON MA 02115 MONTEFIORE MED CTR,DEPT PATHOL BRONX NY 10467 FOX CHASE CANC CTR,DIV MED ONCOL PHILADELPHIA PA 19111 MAYO CLIN ROCHESTER MN 00000
Titolo Testata:
Journal of interferon & cytokine research
fascicolo: 12, volume: 15, anno: 1995,
pagine: 1011 - 1016
SICI:
1079-9907(1995)15:12<1011:LOEOIT>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PAPILLOMAVIRUS INFECTION; POLYMERASE CHAIN-REACTION; GYNECOLOGIC-ONCOLOGY-GROUP; SQUAMOUS-CELL CARCINOMA; UTERINE CERVIX; DEOXYRIBONUCLEIC-ACID; NEOPLASIA; GENE; ASSOCIATION; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
S. Wadler et al., "LACK OF EFFICACY OF INTERFERON-ALPHA THERAPY IN RECURRENT, ADVANCED CERVICAL-CANCER", Journal of interferon & cytokine research, 15(12), 1995, pp. 1011-1016

Abstract

Human papillomavirus (HPV) is associated with 65-95% of in situ or early invasive squamous cell carcinomas of the cervix, A multiinstitutional, prospective phase II clinical trial was initiated by the Eastern Cooperative Oncology Group (ECOG) to study the activity of IFN-alpha 2b in women with metastatic or locally recurrent cervix cancer. The activity of IFN-alpha 2b was correlated with the presence of HPV as measured by Southern blot hybridization or polymerase chain reaction techniques in 17 patients, All patients had failed prior definitive therapy with surgery, radiation; and chemotherapy. IFN-alpha 2b was administered at 10 MU/m(2) subcutaneously three times per week, Among 31 patients enrolled, 3 achieved a clinical response to treatment, Tumor was accessible for biopsy in 17 patients. The presence of HPV was assayed by Southern blot hybridization (2 of 17) and/or polymerase chain reaction(PCR) technology (15 of 17), Of the 17 assays, 16 were informative, HPV was detected in 5 of 16 patients, Of 5 HPV-positive women, 2 responded to treatment, versus 1 of 11 HPV-negative women, thus not permitting reliable statistical analysis, It is concluded that IFN-alpha 2b has only minimal activity against advanced, recurrent cervical cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 05:16:26