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Titolo:
AGE-RELATED-CHANGES IN THE STATIC AND DYNAMIC-MECHANICAL PROPERTIES OF MOUSE LUNGS
Autore:
HIRAI T; HOSOKAWA M; KAWAKAMI K; TAKUBO Y; SAKAI N; OKU Y; CHIN K; OHI M; HIGUCHI K; KUNO K; MISHIMA M;
Indirizzi:
KYOTO UNIV,CHEST DIS RES INST,DEPT SENESCENCE BIOL,SAKYO KU KYOTO 606JAPAN KYOTO UNIV,CHEST DIS RES INST,DEPT SENESCENCE BIOL,SAKYO KU KYOTO 606JAPAN KYOTO UNIV,CHEST DIS RES INST,DEPT CLIN PSYCHOL,SAKYO KU KYOTO 606 JAPAN
Titolo Testata:
Respiration physiology
fascicolo: 2-3, volume: 102, anno: 1995,
pagine: 195 - 203
SICI:
0034-5687(1995)102:2-3<195:AITSAD>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELASTIC RECOIL; CURVE;
Keywords:
COMPLIANCE, STATIC, DYNAMIC LUNG; DEVELOPMENT; MAMMALS, MOUSE; MECHANICS OF BREATHING; RESISTANCE, LUNG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
T. Hirai et al., "AGE-RELATED-CHANGES IN THE STATIC AND DYNAMIC-MECHANICAL PROPERTIES OF MOUSE LUNGS", Respiration physiology, 102(2-3), 1995, pp. 195-203

Abstract

To investigate the effects of aging on pulmonary mechanical properties in mice, we devised a new experimental apparatus to measure the respiratory impedance of excised lungs in mice and examined age-related changes in both static and dynamic properties. In an accelerated senescence-resistant strain of mice, SAMR1 (Takeda, T., Y. Fukuchi, Y. Uejima, K. Teramoto, T. Oka and H. Orino, J. Am. Geriatr. Sec. 39: 911-919, 1991), ranging from 3 to 24 months of age, static compliance (Cst) as well. as total lung capacity increased significantly with age, whereasspecific compliance and the K value, as determined by exponential analysis, showed no significant change. In the dynamic study, dynamic compliance (Cdyn) increased significantly with age, whereas the frequencydependence of Cdyn (Cdyn/Cst) did not vary with age. From these results we concluded that lung elasticity, normalized to lung volume, remained constant with age and that the effects of aging on pulmonary mechanics might be solely derived from increases in lung volume in the SAMR1 strain of mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:28:20