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Titolo:
DIABETOGENIC EFFECTS OF SALMON-CALCITONIN ARE ATTRIBUTABLE TO AMYLIN-LIKE ACTIVITY
Autore:
YOUNG AA; WANG MW; GEDULIN B; RINK TJ; PITTNER R; BEAUMONT K;
Indirizzi:
AMYLIN PHARMACEUT,9373 TOWNE CTR DR SAN DIEGO CA 92121
Titolo Testata:
Metabolism, clinical and experimental
fascicolo: 12, volume: 44, anno: 1995,
pagine: 1581 - 1589
SICI:
0026-0495(1995)44:12<1581:DEOSAA>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENE-RELATED PEPTIDE; ISLET AMYLOID POLYPEPTIDE; STIMULATED INSULIN-SECRETION; PERFUSED RAT PANCREAS; GLYCOGEN-PHOSPHORYLASE; RECEPTOR ANTAGONIST; SOLEUS MUSCLE; GLUCOSE; INVIVO; METABOLISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
58
Recensione:
Indirizzi per estratti:
Citazione:
A.A. Young et al., "DIABETOGENIC EFFECTS OF SALMON-CALCITONIN ARE ATTRIBUTABLE TO AMYLIN-LIKE ACTIVITY", Metabolism, clinical and experimental, 44(12), 1995, pp. 1581-1589

Abstract

During the development of synthetic calcitonins for therapeutic use in hone disease, a ''diabetogenic'' (hyperglycemic) effect was observed, particularly with salmon calcitonin. The effect was attributed by some to inhibition of insulin secretion. We have recently reported high-affinity (28 pmol/L) amylin binding sites in certain areas of rat brain, and found that these sites also bind salmon but not rat calcitonin with comparable high affinity. Rat amylin end salmon calcitonin have been determined to have significant structural homology. In vitro and in vivo studies indicate that rat amylin can exert calcitonin-like effects on osteoclasts and on plasma calcium. Here we report that salmon calcitonin mimics the actions of rat amylin on skeletal muscle glycogenmetabolism in vitro; it stimulates glycogenolysis and inhibits incorporation of radiolabeled glucose into glycogen (50% effective concentration [EC(50)], 0.4 +/- 0.11 nmol/L log and 8.4 +/- 0.05 nmol/L log, respectively). In anesthetized rats, salmon calcitonin, like rat amylin,rapidly increases plasma lactate concentration, followed by a slower increase in glucose concentration. Like amylin, salmon calcitonin alsoinhibits the insulin response to 2 mmol infused glucose (insulin increments suppressed by 52% and 57% at 10 minutes for salmon calcitonin and amylin). Other shared actions, such as suppression of appetite, stimulation of renin secretion, inhibition of gastric acid secretion, andinhibition of gastric emptying, further affirm our proposal that the exogenous peptide, salmon calcitonin, is a mimic of endogenous amylin in the rat. Copyright (C) 1995 by W.B. Saunders Company

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:33:36