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Titolo:
INHIBITORY EFFECTS OF 1-O-HEXYL-2,3,5-TRIMETHYLHYDROQUINONE (HTHQ), GREEN TEA CATECHINS AND OTHER ANTIOXIDANTS ON 2-AMINO-6-METHYLDIPYRIDO[1,2-ALPHA 3',2'-D]IMIDAZOLE (GLU-P-1)-INDUCED RAT HEPATOCARCINOGENESISAND DOSE-DEPENDENT INHIBITION BY HTHQ OF LESION INDUCTION BY GLU-P-1 OR 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-F]QUINOXALINE (MEIQX)/
Autore:
HIROSE M; HASEGAWA R; KIMURA J; AKAGI K; YOSHIDA Y; TANAKA H; MIKI T; SATOH T; WAKABAYASHI K; ITO N; SHIRAI T;
Indirizzi:
NAGOYA CITY UNIV,SCH MED,DEPT PATHOL 1,MIZUHO KU,1 KAWASUMI,MIZUHO CHO NAGOYA AICHI 467 JAPAN NIPPON HYPOX LABS INC,DIV RES & DEV NANBU YAMANASHI 40922 JAPAN TOKUSHIMA BUNRI UNIV,FAC PHARMACEUT SCI YAMASHIRO TOKUSHIMA 770 JAPAN NATL CANC CTR,RES INST,DIV BIOCHEM,CHUO KU TOKYO 104 JAPAN
Titolo Testata:
Carcinogenesis
fascicolo: 12, volume: 16, anno: 1995,
pagine: 3049 - 3055
SICI:
0143-3334(1995)16:12<3049:IEO1(G>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICAL QUENCHERS; METABOLIC-ACTIVATION; 3-AMINO-1-METHYL-5H-PYRIDO)4,3-B>INDOLE TRP-P-2; 3-O-ALKYLASCORBIC ACIDS; CARCINOGENESIS MODEL; HETEROCYCLIC AMINES; LIPID-PEROXIDATION; LUNG TUMORIGENESIS; TUMOR INITIATION; D-LIMONENE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
M. Hirose et al., "INHIBITORY EFFECTS OF 1-O-HEXYL-2,3,5-TRIMETHYLHYDROQUINONE (HTHQ), GREEN TEA CATECHINS AND OTHER ANTIOXIDANTS ON 2-AMINO-6-METHYLDIPYRIDO[1,2-ALPHA 3',2'-D]IMIDAZOLE (GLU-P-1)-INDUCED RAT HEPATOCARCINOGENESISAND DOSE-DEPENDENT INHIBITION BY HTHQ OF LESION INDUCTION BY GLU-P-1 OR 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-F]QUINOXALINE (MEIQX)/", Carcinogenesis, 16(12), 1995, pp. 3049-3055

Abstract

The effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins (GTC), alpha-tocopherol, beta-carotene, chlorophyllin, phenylethylisothiocyanate (PEITC), 3-O-ethylascorbic acid (EAsA), 3-O-dodecylcarbomethyl ascorbic acid (DAsA), n-tritriacontane-16,18-dione (TTAD) and d-limonene on amino-6-methyldipyrido[1,2-alpha:3',2'-d]imidazole (Glu-P-1)- or dimethylnitrosamine (DMN)-induced hepatocarcinogenesis, and the dose dependence of HTHQ inhibition of Glu-P-1- or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-influence on lesion development were examined in a rat medium-term liver bioassay system featuring diethylnitrosamine initiation and partial hepatectomy, At the end of week 8, the number and total area of glutathione S-transferase placental form (GST-P) positive liver foci in rats treated with 0.03 % Glu-P-1 alone were increased significantly (46.8 +/- 11.0 and 12.0 +/- 5.6 respectively) as compared to the control values (3.8 +/- 1.6 and 0.4+/- 0.2), Combined treatment with 1% HTHQ remarkably reduced both of these parameters (8.1 +/- 2.1 and 0.6 +/- 0.2), GTC (1%), PEITC (0.1%), beta-carotene (0.1%) and DAsA (1%) also demonstrated inhibition but less than HTHQ. On the other hand, these antioxidants did not influence development of foci initiated by 0.002% DMN, In the dose-response study, up to 0.125% HTHQ significantly reduced the effects of 0.02% Glu-P-1 or 0.03% MeIQx on the number and area of foci. These results indicate that several antioxidants exert chemopreventive effects against heterocyclic amine (HCA)-induced hepatocarcinogenesis, and particularly HTHQ which thus deserves further attention as a chemopreventor in the context of the environmentally important HCA group of carcinogens.

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Documento generato il 29/11/20 alle ore 00:42:41