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OPAC HELP

Titolo:
EPITOPES FOR HUMAN CD4(-TOXIN - STRUCTURAL FEATURES OF SEQUENCE SEGMENTS FORMING EPITOPES RECOGNIZED BY MOST SUBJECTS() CELLS ON DIPHTHERIA)
Autore:
RAJU R; NAVANEETHAM D; OKITA D; DIETHELMOKITA B; MCCORMICK D; CONTIFINE BM;
Indirizzi:
UNIV MINNESOTA,CBS,DEPT BIOCHEM,1479 GORTNER AVE ST PAUL MN 55108 UNIV MINNESOTA,CBS,DEPT BIOCHEM ST PAUL MN 55108 UNIV MINNESOTA,SCH MED,DEPT PHARMACOL MINNEAPOLIS MN 55455 MAYO CLIN,DEPT BIOCHEM & MOLEC BIOL ROCHESTER MN 00000
Titolo Testata:
European Journal of Immunology
fascicolo: 12, volume: 25, anno: 1995,
pagine: 3207 - 3214
SICI:
0014-2980(1995)25:12<3207:EFHC-S>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ALPHA-SUBUNIT; MYASTHENIA-GRAVIS; ACETYLCHOLINE-RECEPTOR; CLASS-II; SYNTHETIC PEPTIDES; BINDING PEPTIDES; TETANUS TOXIN; HLA-DR1; IDENTIFICATION; TRANSLOCATION;
Keywords:
UNIVERSAL T HELPER EPITOPES; DIPHTHERIA TOXIN; VACCINES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
R. Raju et al., "EPITOPES FOR HUMAN CD4(-TOXIN - STRUCTURAL FEATURES OF SEQUENCE SEGMENTS FORMING EPITOPES RECOGNIZED BY MOST SUBJECTS() CELLS ON DIPHTHERIA)", European Journal of Immunology, 25(12), 1995, pp. 3207-3214

Abstract

The sequence regions of diphtheria toxin (DTX) recognized by CD4(+) Tcells of seven healthy humans of different major histocompatibility complex haplotypes were identified. Overlapping synthetic peptides, screening the DTX sequence, were used to test in proliferation assays unselected blood CD4(+) cells, or DTX-specific CD4(+) lines propagated bystimulation with DTX of blood mononuclear cells. Blood CD4(+) cells and DTX-specific CD4(+) lines gave consistent results. Although each subject had an individual pattern of peptide recognition, six peptide sequences (residues 271-290, 321-340, 331-350, 351-370, 411-430 and 431-450) were recognized by all subjects. In the native DTX molecule, these sequence regions are flanked by sequence loops exposed on the DTX surface. They overlap uncharged segments of the DTX sequence. These structural properties may be general requirements for immunodominance in CD4(+) cell sensitization in humans.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:36:59