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Titolo:
CLINICAL-STUDIES WITH DEXFENFLURAMINE - FROM PAST TO FUTURE
Autore:
GUYGRAND B;
Indirizzi:
HOP HOTEL DIEU,SERV MED & NUTR,PL PARVIS F-75181 PARIS 04 FRANCE
Titolo Testata:
Obesity research
, volume: 3, anno: 1995, supplemento:, 4
pagine: 491 - 496
SICI:
1071-7323(1995)3:<491:CWD-FP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-CALORIE DIET; TERM DEXFENFLURAMINE; OBESE PATIENTS; WEIGHT; GLUCOSE; PATTERNS; EFFICACY; BEHAVIOR; THERAPY; SAFETY;
Keywords:
APPETITE SUPPRESSANTS; SEROTONIN; INDEX STUDY; REVIEW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
B. Guygrand, "CLINICAL-STUDIES WITH DEXFENFLURAMINE - FROM PAST TO FUTURE", Obesity research, 3, 1995, pp. 491-496

Abstract

d Fenfluramine (dF) (15 mg twice daily) has been studied in controlled trials in human obesity, It has been shown to increase adherence to weight Lowering programs, to double the number of patients lo sing 10 kg or more when compared with a fairly efficient placebo plus dietary counselling, and to prevent weight regain when continued over a 1 yearperiod, Weight Loss after 1 month and 4 months is likely to predict subsequent outcome, Also, significant improvement in metabolic risk factors and blood pressure were clearly demonstrated, even more markedly in some obesity-associated diseases,when body weight is maintained at a lower level, Even moderate but sustained weight loss of some 10% of starting weight or less has been confirmed to be of medical value, Tolerance and safety of dF can be considered acceptable, even if longer term follow-up is clearly needed, These studies support the concept that long-term pharmacotherapy with this serotoninergic drug might help achieve better outcome in the management of many obese patients, particularly in preventing relapse, The long-term managerial strategies to be developed for each thus include dF together with dietary advice, behavioral modification and physical exercise, either simultaneously or sequentially.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 19:53:39