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Titolo:
IDENTIFICATION AND CHARACTERIZATION OF A NEW MEMBER OF THE TNF FAMILYTHAT INDUCES APOPTOSIS
Autore:
WILEY SR; SCHOOLEY K; SMOLAK PJ; DIN WS; HUANG CP; NICHOLL JK; SUTHERLAND GR; SMITH TD; RAUCH C; SMITH CA; GOODWIN RG;
Indirizzi:
IMMUNEX RES & DEV CORP,51 UNIV ST SEATTLE WA 98101 WOMENS & CHILDRENS HOSP,DEPT CYTOGENET & MOLEC GENET,CTR MED GENET ADELAIDE SA 5006 AUSTRALIA
Titolo Testata:
Immunity
fascicolo: 6, volume: 3, anno: 1995,
pagine: 673 - 682
SICI:
1074-7613(1995)3:6<673:IACOAN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; MOLECULAR-CLONING; INTERLEUKIN-4 RECEPTOR; HODGKINS LYMPHOMA; ENDOTOXIC-SHOCK; EMERGING FAMILY; CELL-SURFACE; CYTOKINES; LIGAND; HOMOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
S.R. Wiley et al., "IDENTIFICATION AND CHARACTERIZATION OF A NEW MEMBER OF THE TNF FAMILYTHAT INDUCES APOPTOSIS", Immunity, 3(6), 1995, pp. 673-682

Abstract

A novel tumor necrosis factor (TNF) family member has been cloned andcharacterized. This protein, designated TNF-related apoptosis-inducing ligand (TRAIL), consists of 281 and 291 aa in the human and murine forms, respectively, which share 65% aa identity. TRAIL is a type II membrane protein, whose C-terminal extracellular domain shows clear homology to other TNF family members. TRAIL transcripts are detected in a variety of human tissues, most predominantly in spleen, lung, and prostate. The TRAIL gene is located on chromosome 3 at position 3q26, which is not close to any other known TNF ligand family members. Both full-length cell surface expressed TRAIL and picomolar concentrations of soluble TRAIL rapidly induce apoptosis in a wide variety of transformedcell lines of diverse origin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:18:56