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Titolo:
CAFFEINE ELEVATES BLOOD-PRESSURE RESPONSE TO EXERCISE IN MILD HYPERTENSIVE MEN
Autore:
SUNG BH; LOVALLO WR; WHITSETT T; WILSON MF;
Indirizzi:
MILLARD FILLMORE HOSP,DEPT CARDIOL,3 GATES CIRCLE BUFFALO NY 14209
Titolo Testata:
American journal of hypertension
fascicolo: 12, volume: 8, anno: 1995,
parte:, 1
pagine: 1184 - 1188
SICI:
0895-7061(1995)8:12<1184:CEBRTE>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Keywords:
CAFFEINE; HYPERTENSION; EXERCISE; BLOOD PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
B.H. Sung et al., "CAFFEINE ELEVATES BLOOD-PRESSURE RESPONSE TO EXERCISE IN MILD HYPERTENSIVE MEN", American journal of hypertension, 8(12), 1995, pp. 1184-1188

Abstract

The present study examined the effects of caffeine on blood pressure (BP) regulation in hypertensive men during exercise. Twenty unmedicated, mild hypertensives (HT, BP= 140/90 to 160/105 mm Hg) and 12 age-matched, normotensives (NT, BP < 130/80 mm Hg) performed 30 min of extended bicycle exercise following a single dose of caffeine (3.3 mg/kg, equivalent to 2 to 3 cups of coffee) and placebo in a double-blind, cross-over design. Hemodynamic measurements were made at predrug, 40-min postdrug and during exercise. At predrug baseline, HT had significantlyhigher HR (67 v 57 beats/min) and BP (141/96 v 118/72 mm Hg) than NT. At postdrug baseline, caffeine increased systolic and diastolic BP, and peripheral vascular resistance (P <.01 in all cases), decreased HR (P < .05) and did not significantly change stroke volume and cardiac output for both groups. During; exercise, HR response was greater on caffeine day than placebo day in HT (P < 0.05) only. Systolic BP was consistently elevated on caffeine day compared to placebo day in both groups (P <.001). Diastolic BP was elevated in HT for 30 min of exercise on caffeine day, but this presser effect disappeared at 15 min of exercise in NT. As a result, rate-pressure products were significantly higher on caffeine days in HT at postdrug and during exercise. On caffeine day, 7 (39%) HT and 1 (8%) NT showed an excessive BP response (>230 for systolic or >120 for diastolic) during exercise. In conclusion, caffeine has significant hemodynamic effects on mild hypertensives at rest and during exercise. The increased rate-pressure products followingcaffeine during exercise place a greater workload on the heart, and abstinence from caffeine, especially before exercise, may be beneficialfor persons with hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/10/20 alle ore 12:10:07