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Titolo:
STIMULATORY EFFECT OF OUABAIN ON VCAM-1 AND INOS EXPRESSION IN MURINEENDOTHELIAL-CELLS - INVOLVEMENT OF NF-KAPPA-B
Autore:
BERETA J; COHEN MC; BERETA M;
Indirizzi:
JAGIELLONIAN UNIV,INST MOLEC BIOL,AL MICKIEWICZA 3 PL-31120 KRAKOW POLAND UNIV MED & DENT NEW JERSEY,NEW JERSEY MED SCH,DEPT ANAT CELL BIOL & INJURY SCI NEWARK NJ 07103
Titolo Testata:
FEBS letters
fascicolo: 1, volume: 377, anno: 1995,
pagine: 21 - 25
SICI:
0014-5793(1995)377:1<21:SEOOOV>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; PROMOTER; LIPOPOLYSACCHARIDE; IDENTIFICATION; ADHESION; COMPOUND; EXCHANGE; RELEASE; PLASMA;
Keywords:
OUABAIN; NA+/K+-ATPASE; VCAM-1; INOS; NF-KAPPA-B;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
J. Bereta et al., "STIMULATORY EFFECT OF OUABAIN ON VCAM-1 AND INOS EXPRESSION IN MURINEENDOTHELIAL-CELLS - INVOLVEMENT OF NF-KAPPA-B", FEBS letters, 377(1), 1995, pp. 21-25

Abstract

Endothelial cells play a pivotal role in the development of atherosclerosis, An 'activated' phenotype of these cells is manifested by signal transduction-dependent expression of genes encoding cytokines, pro- and anticoagulant factors, and cell adhesion molecules. In the currentstudy we examined the effect of ouabain, an inhibitor of Na+/K+-ATPase, on the process of endothelial cell activation, We demonstrated thatouabain was able to stimulate VCAM-1 expression and potentiate the effect of IFN-gamma on this process, Moreover, ouabain provided a complementary signal for either TNF or IFN-gamma in inducing iNOS expression, Our data also show, for the first time, that inhibition of Na+/K+-ATPase led to activation of the transcription factor, NF-kappa B, which may provide an explanation for the effects of ouabain on endothelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:28:10