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Titolo:
SYNTHESIS AND SEROTONIN RECEPTOR-BINDING PROPERTIES OF 5-SUBSTITUTED 3-(1',2',5',6'-TETRAHYDROPYRIDIN-3'-YL) INDOLES
Autore:
DAHLGREN T; DEAN RL; GHARAT LA; JOHANSSON AM; LAMBERT G; LI HB; NELSON DL; YANG Y; MARTIN AR;
Indirizzi:
UNIV ARIZONA,COLL PHARM,DEPT PHARMACOL & TOXICOL TUCSON AZ 85721 UNIV ARIZONA,COLL PHARM,DEPT PHARMACOL & TOXICOL TUCSON AZ 85721
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 24, volume: 5, anno: 1995,
pagine: 2963 - 2968
SICI:
0960-894X(1995)5:24<2963:SASRPO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOGNITION SITES; RU-24969; ANALOGS; AGONIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
T. Dahlgren et al., "SYNTHESIS AND SEROTONIN RECEPTOR-BINDING PROPERTIES OF 5-SUBSTITUTED 3-(1',2',5',6'-TETRAHYDROPYRIDIN-3'-YL) INDOLES", Bioorganic & medicinal chemistry letters, 5(24), 1995, pp. 2963-2968

Abstract

A semi-rigid 5-hydroxytryptamine (5-HT) analogue, RU28253 [5-methoxy-3-(1',2',5',6'-tetrahydropyridin-3'-yl) indole], is a potent 5-HT1 and5-HT2 agonist. It is isomeric to RU24969 [5-methoxy-3-(1',2',5',6'-tetrahydropyridin-4'-yl) indole], a conformationally restricted 5-HT homologue, which has been extensively used in the study and classification of 5-HT receptors. A series of RU28253 derivatives with diverse substituents on indole 5-position were synthesized and their dissociation constants determined at the 5-HT1 and 5-HT2 receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 15:03:54