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Titolo:
DIFFERENT RESPONSES OF ARTERIOLES AND VENULES IN RAT GASTRIC-MUCOSAL MICROCIRCULATION TO ENDOTHELIN-1 AND ENDOTHELIN-3
Autore:
OHNO T; KATORI M; MAJIMA M; HAYASHI H; SAIGENJI K;
Indirizzi:
KITASATO UNIV,SCH MED,DEPT PHARMACOL,1-15-1 KITASATO SAGAMIHARA KANAGAWA 228 JAPAN KITASATO UNIV,SCH MED,DEPT PHARMACOL SAGAMIHARA KANAGAWA 228 JAPAN KITASATO UNIV,SCH MED,DEPT INTERNAL MED SAGAMIHARA KANAGAWA 228 JAPAN
Titolo Testata:
Journal of clinical gastroenterology
, volume: 21, anno: 1995, supplemento:, 1
pagine: 56 - 65
SICI:
0192-0790(1995)21:<56:DROAAV>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED VASOCONSTRICTION; FUNCTIONAL EXPRESSION; MOLECULAR-CLONING; RECEPTOR; CDNA; ETHANOL; INJURY; MICROVASCULATURE; STOMACH; VESSELS;
Keywords:
GASTRIC MUCOSAL MICROCIRCULATION; ENDOTHELIN-1; ENDOTHELIN-3; BQ-123; SARAFOTOXIN S6C; ET(A) RECEPTOR; ET(B) RECEPTOR; PROSTAGLANDIN I-2; NITRIC OXIDE; L-NMMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
T. Ohno et al., "DIFFERENT RESPONSES OF ARTERIOLES AND VENULES IN RAT GASTRIC-MUCOSAL MICROCIRCULATION TO ENDOTHELIN-1 AND ENDOTHELIN-3", Journal of clinical gastroenterology, 21, 1995, pp. 56-65

Abstract

Responses of the microvessels in the basal part of the gastric mucosaof anesthetized rats to endothelin (ET)-1 and ET-3 were examined by intravital microscopy. The posterior wall of the stomach, which was incised along the greater curvature, was secured in an observation chamber and superfused with Tyrode's solution, and the microcirculation was observed through a window made by removing a limited area of smooth-muscle layers with the serosa and submucosal tissue. Topical applicationof the same ranges of ET-1 and ET-3 (0.1-10 mu M, 20 mu l) to the window dose-dependently constricted collecting venules and venules downstream. The constriction was inhibited by BQ-123, an ET(A) receptor antagonist, but the equipotency of ET-1 and ET-3 did not support the presence of the ET(A) receptor (tentatively called ETR-m). Arterioles were constricted through ETR-m, particularly at higher doses (> 3 mu M), but 1 mu M ET-1 dilated the arterioles by generating prostaglandin through BQ-123-sensitive ET receptor (tentatively called ETR-e), as shown by the inhibition of dilatation by indomethacin. Furthermore, the dilatation component of the arteriolar smooth-muscle responses to ET-1 and ET-3 was elicited by BQ-123 and was inhibited by N-G-monomethyl-L-arginine (L-NMMA), indicating the generation of nitric oxide. This dilating effect of the endothelins was mediated by the ET(B) receptor.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 12:21:36