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Titolo:
NEW ANTITHROMBOTIC AGENTS
Autore:
KEREVEUR A; SAMAMA MM;
Indirizzi:
HOP HOTEL DIEU,SERV HEMATOL BIOL,1 PL PARVIS NOTRE DAME F-75181 PARIS04 FRANCE HOP HOTEL DIEU,SERV HEMATOL BIOL F-75181 PARIS 04 FRANCE
Titolo Testata:
La Presse medicale
fascicolo: 38, volume: 24, anno: 1995,
pagine: 1777 - 1787
SICI:
0755-4982(1995)24:38<1777:NAA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
FRE
Soggetto:
HEPARIN-INDUCED THROMBOCYTOPENIA; SYNTHETIC THROMBIN INHIBITOR; COAGULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
A. Kereveur e M.M. Samama, "NEW ANTITHROMBOTIC AGENTS", La Presse medicale, 24(38), 1995, pp. 1777-1787

Abstract

The wide range of compounds currently being developed is the result of the continuing need for validated new antithrombotic agents. The prevention and treatment of venous thrombosis is predominated by anticoagulants: low molecular weight heparins, and potentially new antithrombin agents including hirudin. The effectiveness of new antiplatelet agents, and particularly c7E3 and integrelin, confirms the hypothesis concerning the role played by platelets in thrombogenesis in coronary arteries. But, due to the proaggregating effect of thrombin, anticoagulants could also have an important role in preventing arterial clots, either when given alone or in combination. Finally, the development of antithrombin and anti-platelet-glycoprotein IIb, IIIa given orally is oneof the major objectives of current research, Until the ideal antithrombotic agent is discovered, multiple-drug regimens combining anticoagulants and/or antiplatelet agents could be proposed in patients with a very high risk of thrombosis. Such regimens must take into account theincreased risk of bleeding and be adapted on the basis of careful laboratory surveillance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 18:36:23