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Titolo:
GENDER DIFFERENCES IN PATTERNS OF HPA AXIS RESPONSE TO CHALLENGE - MACARTHUR STUDIES OF SUCCESSFUL AGING
Autore:
SEEMAN TE; SINGER B; CHARPENTIER P;
Indirizzi:
UNIV SO CALIF,ETHEL PERCY ANDRUS GERONTOL CTR,UNIV PK LOS ANGELES CA 90089 YALE UNIV,SCH MED,EPIDEMIOL & PUBL HLTH LAB NEW HAVEN CT 06520 PRINCETON UNIV,OFF POPULAT RES PRINCETON NJ 08544
Titolo Testata:
Psychoneuroendocrinology
fascicolo: 7, volume: 20, anno: 1995,
pagine: 711 - 725
SICI:
0306-4530(1995)20:7<711:GDIPOH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PITUITARY-ADRENAL RESPONSE; NEURO-ENDOCRINE RESPONSES; SEX-DIFFERENCES; FEMALE RATS; PLASMA ADRENOCORTICOTROPIN; GLUCOCORTICOID RESPONSE; POSTMENOPAUSAL WOMEN; STRESS RESPONSES; ETHER STRESS;
Keywords:
HPA AXIS; CORTISOL; ACTH; GENDER; HPA REACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
T.E. Seeman et al., "GENDER DIFFERENCES IN PATTERNS OF HPA AXIS RESPONSE TO CHALLENGE - MACARTHUR STUDIES OF SUCCESSFUL AGING", Psychoneuroendocrinology, 20(7), 1995, pp. 711-725

Abstract

Previous research has suggested that women may have greater and more prolonged hypothalamic-pituitary-adrenal response to challenge at older ages. Data on patterns of ACTH and cortisol responses to a ''naturalistic'' driving simulation challenge were examined to test the hypothesis that older women (aged 70-79 years) would show greater response than a comparable group of older men. Analyses of mean ACTH or cortisol responses in terms of maximal increase, area under the curve and repeated measures ANOVA did not reveal significant gender differences. By contrast, analyses of the joint occurrence of ACTH and cortisol responses above the respective sample medians indicated that women were significantly more likely to respond to the challenge with elevated ACTH and cortisol responses. The lack of significant gender difference in theanalyses of mean scores resulted from the sensitivity of this measureof typicality (or average response) to outliers in the data, thereby substantially distorting the report of typical (or average) responses for the male population. Analyses of the temporal patterns of ACTH andcortisol response in terms of the stability of the subject's relativerank at each sampling time indicated that: (1) there was considerablestability of rankings based on the initial cortisol response (though not ACTH) through the recovery period; and (2) women exhibited greaterinstability than men, being more likely to exhibit shifts in rank from high to low over time. These findings suggest that: (1) as a group, older women are more likely to show larger responses than comparably healthy older men to a ''naturalistic'' driving simulation challenge; (2) there is considerable stability in patterns of cortisol response from initial response at 20 min through the recovery period, indicating that those showing greater initial response continue to experience higher levels of cortisol during the post-challenge recovery period; and (3) instability is more common among women than men.

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Documento generato il 28/09/20 alle ore 12:16:07