Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFICACY OF ACELLULAR PERTUSSIS-VACCINE IN EARLY-CHILDHOOD AFTER HOUSEHOLD EXPOSURE
Autore:
SCHMITT HJ; VONKONIG CHW; NEISS A; BOGAERTS H; BOCK HL; SCHULTEWISSERMANN H; GAHR M; SCHULT R; FOLKENS JU; RAUH W; CLEMENS R;
Indirizzi:
CHRISTIAN ALBRECHTS UNIV KIEL,CHILDRENS HOSP,SCHWANENWEG 20 D-24105 KIEL GERMANY UNIV MAINZ,CHILDRENS HOSP W-6500 MAINZ GERMANY MUNICIPAL HOSP KREFELD,INST HYG & LAB MED KREFELD GERMANY MUNICIPAL HOSP KREFELD,CHILDRENS HOSP KREFELD GERMANY TECH UNIV MUNICH,INST MED STAT & EPIDEMIOL W-8000 MUNICH GERMANY SMITHKLINE BEECHAM BIOL RIXENSART BELGIUM UNIV GOTTINGEN,CHILDRENS HOSP W-3400 GOTTINGEN GERMANY PEDIATRICIANS FLENSBURG FLENSBURG GERMANY CHILDRENS HOSP OFFENBURG OFFENBURG GERMANY MUTTERHAUS BORROMAERINNEN,CHILDRENS HOSP TRIER GERMANY
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 1, volume: 275, anno: 1996,
pagine: 37 - 41
SICI:
0098-7484(1996)275:1<37:EOAPIE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
H.J. Schmitt et al., "EFFICACY OF ACELLULAR PERTUSSIS-VACCINE IN EARLY-CHILDHOOD AFTER HOUSEHOLD EXPOSURE", JAMA, the journal of the American Medical Association, 275(1), 1996, pp. 37-41

Abstract

Objective.-To evaluate the efficacy of a three-dose primary vaccination with a diphtheria-tetanus tricomponent acellular pertussis vaccine against ''typical'' pertussis, defined as a spasmodic cough of 21 daysor longer with confirmation of Bordetella pertussis infection by culture or serology. Design.-Passive monitoring for suspected first household (index) cases of typical pertussis in six areas in Germany comprising 22 505 children vaccinated with study vaccine at 3, 4, and 5 months of age. Blinded, prospective follow-up of household contacts of index cases for incidence and progression of pertussis. Setting.-Six areasin Germany with a high incidence of pertussis, Subjects.-Four hundredfifty-three households with index cases comprising 360 evaluable contacts eligible for analysis of vaccine efficacy. Main Outcome Measure.-Vaccine efficacy from attack rates of pertussis in household contacts classified by vaccination status. Results.-Of the 173 nonvaccinated household contacts, 96 developed typical pertussis, compared with seven of 112 contacts vaccinated with acellular pertussis vaccine. Vaccine efficacy was consequently calculated to be 88.7% (95% confidence interval, 76.6% to 94.6%). Protection did not wane until at least the time recommended for booster vaccination. None of the analyzed potential confounding factors-age, socioeconomic status, erythromycin treatment, household composition, center effect, and selection bias-influenced study results in favor of the vaccine. Conclusions.-Under conditions of intense household exposure, primary vaccination with acellular vaccine protected against pertussis until at least the time recommended for booster vaccination, The vaccine can be expected to be equally or more effective in settings with lower infectious pressure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:45:24