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Titolo:
ASSESSMENT OF CARDIORESPIRATORY FUNCTION USING OSCILLATING INERT-GAS FORCING SIGNALS
Autore:
WILLIAMS EM; ASPEL JB; BURROUGH SML; RYDER WA; SAINSBURY MC; SUTTON L; XIONG L; BLACK AMS; HAHN CEW;
Indirizzi:
UNIV OXFORD,RADCLIFFE INFIRM,NUFFIELD DEPT ANAESTHET,WOODSTOCK RD OXFORD OX2 6HE ENGLAND UNIV OXFORD,RADCLIFFE INFIRM,NUFFIELD DEPT ANAESTHET OXFORD OX2 6HE ENGLAND UNIV BRISTOL,BRISTOL ROYAL INFIRM,SIR HUMPHRY DAVY DEPT ANAESTHESIA BRISTOL BS2 8HW ENGLAND
Titolo Testata:
Journal of applied physiology
fascicolo: 5, volume: 76, anno: 1994,
pagine: 2130 - 2139
SICI:
8750-7587(1994)76:5<2130:AOCFUO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONINVASIVE CARDIAC-OUTPUT; SULFUR-HEXAFLUORIDE WASHOUT; RESIDUAL CAPACITY; MECHANICAL VENTILATION; CARBON-DIOXIDE; THERMODILUTION; EXCHANGE; PEEP; LUNG; RESPIRATION;
Keywords:
ALVEOLAR VOLUME; AIRWAY DEAD SPACE; PULMONARY BLOOD FLOW; SINUSOID TECHNIQUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Williams et al., "ASSESSMENT OF CARDIORESPIRATORY FUNCTION USING OSCILLATING INERT-GAS FORCING SIGNALS", Journal of applied physiology, 76(5), 1994, pp. 2130-2139

Abstract

A theoretical model (Hahn et al. J. Appl. Physiol. 75: 1863-1876, 1993) predicts that the amplitudes of the argon and nitrous oxide inspired, end-expired, and mixed expired sinusoids at forcing periods in the range of 2-3 min (frequency 0.3-0.5 min(-1)) can be used directly to measure airway dead space, lung alveolar volume, and pulmonary blood flow. We tested the ability of this procedure to measure these parameters continuously by feeding monosinusoidal argon and nitrous oxide forcing signals (6 +/- 4% vol/vol) into the inspired airstream of nine anesthetized ventilated dogs. Close agreement was found between single-breath and sinusoid airway dead space measurements (mean difference 15 +/- 6%, 95% confidence limit), N-2 washout and sinusoid alveolar volume (mean difference 4 +/- 6%, 95% confidence limit), and thermal dilutionand sinusoid pulmonary blood flow (mean difference 12 +/- 11%, 95% confidence limit). The application of 1 kPa positive end-expiratory pressure increased airway dead space by 12% and alveolar volume from 0.8 to 1.1 liters but did not alter pulmonary blood flow, as measured by both the sinusoid and comparator techniques. Our findings show that the noninvasive sinusoid technique can be used to measure cardiorespiratory lung function and allows changes in function to be resolved in 2 min.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 08:01:32