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Titolo:
ESTIMATED TIMING OF MOTHER-TO-CHILD HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) TRANSMISSION BY USE OF A MARKOV MODEL
Autore:
ROUZIOUX C; COSTAGLIOLA D; BURGARD M; BLANCHE S; MAYAUX MJ; GRISCELLI C; VALLERON AJ; ALLEMON MC; ARMENGAUD D; BABINET JM; BALDE P; BENFADEL F; BENSADOUN R; BERTEROTIERE D; BODDAERT M; BOMPARD Y; BOTTO C; BRUNNER AM; CACAULT JA; CARLUSMONCOMBLE C; CIRARUVIGNERON N; COHEN C; COLINGORKI AM; COURPOTIN C; CRUMIERE C; DALLOT MC; DANDINE M; DECREPY A; DEBONS M; DEBRE M; DENAVIT MF; DEVIDAS A; DUMONTEL M; FIRTION G; FLOCH C; FRANCOUAL C; FURIOLI J; GANTZER A; GRANIER F; GUILLOT F; HELLER B; HURAUXRENDU C; LABRUNE P; LACHASSINE E; LACROIX A; LANZA M; LAJALLE H; LELORIER B; LEBLANC A; LEBRUN F; LEJEUNE C; MAMOU J; MAY A; MAZI F; MEYER A; MOUCHNINO G; NARCY P; NOSEDA G; PASCAL C; PAUTARD B; ROBIN M; RONZIER M; ROPERT JL; ROUSSET MC; SAILLANT A; SCART G; SEAUME H; SEGUY D; TALON P; TARDIEU M; TERRIS J; VALDES L; VEBER F; VEDRENNE J; VIAL M; VINAS A; VINCENT N; WIPFF P;
Indirizzi:
HOP NECKER ENFANTS MALAD,VIROL LAB,149 RUE SEVRES F-75015 PARIS FRANCE UNIV PARIS 06,FAC MED ST ANTOINE,INSERM,U263,B3E PARIS FRANCE UNIV PARIS 06,FAC MED ST ANTOINE,INSERM,U263,SC4 PARIS FRANCE HOP NECKER ENFANTS MALAD,UNITE IMMUNOL HEMATOL F-75015 PARIS FRANCE HOP KREMLIN BICETRE,INSERM,U292 LE KREMLIN BICETR FRANCE
Titolo Testata:
American journal of epidemiology
fascicolo: 12, volume: 142, anno: 1995,
pagine: 1330 - 1337
SICI:
0002-9262(1995)142:12<1330:ETOMHT>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIBODY-PRODUCTION; INFECTION; INFANTS; CULTURE; WOMEN;
Keywords:
COHORT STUDIES; HIV-1; MARKOV MODELS; MOTHER-TO-CHILD TRANSMISSION; STATISTICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
C. Rouzioux et al., "ESTIMATED TIMING OF MOTHER-TO-CHILD HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 (HIV-1) TRANSMISSION BY USE OF A MARKOV MODEL", American journal of epidemiology, 142(12), 1995, pp. 1330-1337

Abstract

It has been shown that mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission can occur both during pregnancy and at delivery, but the respective frequencies in these periods are unknown. Moreover, it is difficult to determine the timing of mother-to-child HIV-I transmission by direct sampling, The use of an elaborate statisticalmethod is therefore necessary. The authors studied 495 consecutive infants born between May 1988 and August 1991 who were included, at birth, in the French Prospective Study on Pediatric HIV Infection. At least one blood sample was obtained from every infant during the first 14 days of life. All samples obtained within 3 months of birth were tested by at least two of the following methods: viral culture, polymerase chain reaction (PCR), and antigenemia, as well as by Western blot test. Data for the 95 infected infants (those seropositive at 18 months and those who died of HIV disease before this age), and who were exclusively bottle-fed, were analyzed in a Markov model to estimate the timing of viral transmission, the time from birth to the emergence of detectable virus, and the time from birth to seroconversion. The model indicated that one-third of the infants were infected in utero, less than 2 months before delivery (95th percentile). In the remaining 65% of cases (95% confidence interval (CI) 22-92), the date of infection was estimated as the day of birth. The estimated median period between birthand the emergence of viral markers was 10 days (95% CI 6-14) and the 95th percentile was estimated at 56 days. These results support the view that HIV infection can be diagnosed during the first 3 months of life. The authors conclude that mother-to-child HIV-1 transmission appears to occur late in pregnancy or at delivery.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 20:10:51