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Titolo:
ATTENUATED MICROVASCULAR PERFUSION AND REACTIVITY IN CARDIAC TRANSPLANT RECIPIENTS TREATED WITH CYCLOSPORINE
Autore:
ANDREASSEN AK; SIMONSEN S; BJORNERHEIM R; KVERNEBO K;
Indirizzi:
RIGSHOSP,DEPT MED,CARDIOL SECT N-0027 OSLO NORWAY ULLEVAL HOSP,DEPT SURG,CARDIOVASC SURG SECT OSLO NORWAY
Titolo Testata:
International journal of microcirculation, clinical and experimental
fascicolo: 3, volume: 15, anno: 1995,
pagine: 117 - 124
SICI:
0167-6865(1995)15:3<117:AMPARI>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; IDIOPATHIC DILATED CARDIOMYOPATHY; LASER DOPPLER FLOWMETRY; PERIPHERAL-CIRCULATION; SYMPATHETIC ACTIVATION; BLOOD-FLOW; THERAPY; HYPERTENSION; ENDOTHELIUM; SECONDARY;
Keywords:
CARDIAC TRANSPLANT RECIPIENTS; LASER DOPPLER PERFUSION MEASUREMENTS; MICROVASCULAR REACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Andreassen et al., "ATTENUATED MICROVASCULAR PERFUSION AND REACTIVITY IN CARDIAC TRANSPLANT RECIPIENTS TREATED WITH CYCLOSPORINE", International journal of microcirculation, clinical and experimental, 15(3), 1995, pp. 117-124

Abstract

Orthotopic heart transplant recipients (TX pts) treated with cyclosporine develop postoperative hypertension and their functional capacity remains less than normal. Altered responsiveness to adrenegic stimuli and impaired release of endothelial-derived relaxing factor are proposed mechanisms of cyclosporine-induced raised peripheral vascular resistance. We compared responses to vasoconstrictor tests that stimulate sympathetic neural outflow (Valasalva maneuver and cold presser test) and a vasodilator test that is dependent on the presence of a functionally intact endothelium (postocclusive hyperemia) in 16 TX pts with age-matched healthy controls, applying laser Doppler perfusion measurements (LDPM). Mean time since transplantation was 4.5 years (1-10 years). All TX pts received the triple regimen of prednisone, azathioprine and cyclosporine. Fourteen were considered hypertensive. Basal LDPM at rest expressed in arbitrary flux units (AU), was significantly lower inthe TX pts (15.9 AU) than the controls (21.5 AU; p < 0.01). The maximal flux changes in the vasoconstrictor and vasodilator responses were comparable. However, the TX pts recovered faster from these responses and flux values at mid-to-late phase were lower following peak hyperemia and higher at any point following a cold presser test than in the controls. Furthermore, a correlation was found between flux levels 30 safter either stimulus (r = 0.56; p < 0.0009) and time to reach prestimulus baseline after either test (r = 0.55; p < 0.002). With indirect evidence of comparable microvascular architecture, our findings suggest endothelial dysfunction in TX pts with intact functional capacity ofthe sympathetic nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/10/20 alle ore 04:41:06