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Titolo:
ANTIMALARIAL PROPERTIES OF SOY-BEAN FAT EMULSIONS
Autore:
DEHARO E; KRUGLIAK M; BACCAM D; GINSBURG H;
Indirizzi:
HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL HEBREW UNIV JERUSALEM,INST LIFE SCI,DEPT BIOL CHEM IL-91904 JERUSALEMISRAEL MUSEUM NATL HIST NAT,CNRS,BIOL PARASITAIRE LAB,URA 114 F-75231 PARIS 05 FRANCE MUSEUM NATL HIST NAT,CNRS,PROTOZOOL & PARASITOL COMPAREE LAB F-75231 PARIS 05 FRANCE
Titolo Testata:
International journal for parasitology
fascicolo: 12, volume: 25, anno: 1995,
pagine: 1457 - 1462
SICI:
0020-7519(1995)25:12<1457:APOSFE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM; VITAMIN-E; INFECTED ERYTHROCYTES; MALARIA; INVITRO; ACIDS; DRUGS; CONSUMPTION; ABSORPTION; DISEASE;
Keywords:
MALARIA; PLASMODIUM FALCIPARUM; P-VINCKEI PETTERI; P-BERGHEI; P-YOELII NIGERIENSIS; SOY-BEAN FAT EMULSION; DRUG;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
E. Deharo et al., "ANTIMALARIAL PROPERTIES OF SOY-BEAN FAT EMULSIONS", International journal for parasitology, 25(12), 1995, pp. 1457-1462

Abstract

Intralipid(R) and Ivelip(R) are commercial preparations of soy-bean lipid extracts used for intravenous supplementation of lipids in various clinical conditions. They were found to inhibit the growth of Plasmodium falciparum in culture with an IC50 of 8.07 +/- 2.13 and 13.32 +/-2.05 mg.ml(-1), respectively. Intralipid(R) rapidly and efficiently inhibited nucleic acid synthesis in cultured P. falciparum, exhibiting full inhibitory activity in less than 2 h. Ivelip(R) injected intraperitoneally, was found by the 4-day suppressive test to be active in vivo against P. vinckei petteri within the normal recommended regimen fordietary lipid supply (0.5-4 g.kg(-1)), but it was impossible to obtain a radical cure even with very high doses (6.4 g.kg(-1)). Ivelip(R) was less effective against P. berghei and P. yoelii nigeriensis. As Ivelip(R) showed no interference with the antimalarial activity of chloroquine, it could be considered for use in the treatment of severe humanmalaria in association with 4-aminoquinolines to expedite the clearance of parasites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:38:54