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Titolo:
OPTIMAL RADIATION BEAM PROFILES CONSIDERING THE STOCHASTIC-PROCESS OFPATIENT POSITIONING IN FRACTIONATED RADIATION-THERAPY
Autore:
LOF J; LIND BK; BRAHME A;
Indirizzi:
KAROLINSKA INST,DEPT RADIAT PHYS,POB 260 S-17176 STOCKHOLM SWEDEN UNIV STOCKHOLM S-17176 STOCKHOLM SWEDEN
Titolo Testata:
Inverse problems
fascicolo: 6, volume: 11, anno: 1995,
pagine: 1189 - 1209
SICI:
0266-5611(1995)11:6<1189:ORBPCT>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NORMAL TISSUE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
CompuMath Citation Index
CompuMath Citation Index
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
J. Lof et al., "OPTIMAL RADIATION BEAM PROFILES CONSIDERING THE STOCHASTIC-PROCESS OFPATIENT POSITIONING IN FRACTIONATED RADIATION-THERAPY", Inverse problems, 11(6), 1995, pp. 1189-1209

Abstract

We present a solution to the problem of finding optimal beam profilesin fractionated radiation therapy when taking the uncertainty in beampatient alignment into account. The problem was previously solved forthe special cases of one single dose fraction and infinitely many fractions. For few fractions (less than or equal to 5), symmetry considerations reduce the problem so that it can be handled with ordinary numerical integration techniques. For the general case, including the frequently used 20-30 fractions, a Monte Carlo integration method has beendeveloped. As may be expected, a linear response model for radiation sensitivity, based only on the total dose delivered, is insufficient for a large number of dose fractions with sharp beam edges. Under such circumstances the full linear quadratic model for cell survival has tobe incorporated. The standard technique of opening up the fields to compensate for the positioning uncertainty is only feasible when the surrounding normal tissues tolerate radiation well. The present studies indicate that the probability of achieving tumour control without inducing severe injury to normal tissue can be increased if optimal non-uniform beams are used.

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Documento generato il 28/11/20 alle ore 18:29:22