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Titolo:
K+ CHANNEL OPENERS DELAY INTESTINAL TRANSIT AND HAVE ANTIDIARRHEAL ACTIVITY
Autore:
POGGIOLI R; BENELLI A; ARLETTI R; CAVAZZUTI E; BERTOLINI A;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA ITALY
Titolo Testata:
European journal of pharmacology
fascicolo: 2, volume: 287, anno: 1995,
pagine: 207 - 209
SICI:
0014-2999(1995)287:2<207:KCODIT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Keywords:
K-ATP CHANNEL OPENER; PINACIDIL; CROMAKALIM; MORPHINE; INTESTINAL TRANSIT; DIARRHEA;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
R. Poggioli et al., "K+ CHANNEL OPENERS DELAY INTESTINAL TRANSIT AND HAVE ANTIDIARRHEAL ACTIVITY", European journal of pharmacology, 287(2), 1995, pp. 207-209

Abstract

The effect of pinacidil and cromakalim, two K-ATP channel openers, onintestinal transit and castor oil-induced diarrhea was studied in mice. Both drugs, administered orally, dose dependently inhibited the intestinal propulsion of charcoal, and castor oil-induced diarrhea, comparing favorably with morphine. These results may suggest a new approachfor the symptomatic treatment of diarrhea.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:47:28