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Titolo:
DIFFERENTIATION OF IMMORTAL CELLS INHIBITS TELOMERASE ACTIVITY
Autore:
SHARMA HW; SOKOLOSKI JA; PEREZ JR; MALTESE JY; SARTORELLI AC; STEIN CA; NICHOLS G; KHALED Z; TELANG NT; NARAYANAN R;
Indirizzi:
HOFFMANN LA ROCHE INC,ROCHE RES CTR,DIV ONCOL,340 KINGSLAND ST NUTLEYNJ 07110 HOFFMANN LA ROCHE INC,ROCHE RES CTR,DIV ONCOL NUTLEY NJ 07110 YALE UNIV,SCH MED,CTR CANC,DEPT PHARMACOL NEW HAVEN CT 06520 YALE UNIV,SCH MED,CTR CANC,DEV THERAPEUT PROGRAM NEW HAVEN CT 06520 COLUMBIA UNIV COLL PHYS & SURG,DEPT MED NEW YORK NY 10032 STRANG CORNELL CANC RES LAB NEW YORK NY 10021
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 26, volume: 92, anno: 1995,
pagine: 12343 - 12346
SICI:
0027-8424(1995)92:26<12343:DOICIT>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; P65 SUBUNIT;
Keywords:
CANCER; TELOMERES; RIBONUCLEOPROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
H.W. Sharma et al., "DIFFERENTIATION OF IMMORTAL CELLS INHIBITS TELOMERASE ACTIVITY", Proceedings of the National Academy of Sciences of the United Statesof America, 92(26), 1995, pp. 12343-12346

Abstract

Telomerase, a ribonucleic acid-protein complex, adds hexameric repeats of 5'-TTAGGG-3' to the ends of mammalian chromosomal DNA (telomeres)to compensate for the progressive loss that occurs with successive rounds of DNA replication. Although somatic cells do not express telomerase, germ cells and immortalized cells, including neoplastic cells, express this activity. To determine whether the phenotypic differentiation of immortalized cells is linked to the regulation of telomerase activity, terminal differentiation was induced in leukemic cell lines by diverse agents. A pronounced downregulation of telomerase activity wasproduced as a consequence of the differentiated status. The differentiation-inducing agents did not directly inhibit telomerase activity, suggesting that the inhibition of telomerase activity is in response toinduction of differentiation. The loss of telomerase activity was notdue to the production of an inhibitor, since extracts from differentiated cells did not cause inhibition of telomerase activity, By using additional cell lineages including epithelial and embryonal stem cells,down-regulation of telomerase activity was found to be a general response to the induction of differentiation. These findings provide the first direct link between telomerase activity and terminal differentiation and may provide a model to study regulation of telomerase activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:35:46