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Titolo:
DETERMINATION OF ALPRAZOLAM AND ITS MAJOR METABOLITES IN SERUM MICROSAMPLES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND ITS APPLICATION TO PHARMACOKINETICS IN RATS
Autore:
JIN LY; LAU CE;
Indirizzi:
RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903 RUTGERS STATE UNIV,DEPT PSYCHOL NEW BRUNSWICK NJ 08903
Titolo Testata:
Journal of chromatography B. Biomedical applications
fascicolo: 1, volume: 654, anno: 1994,
pagine: 77 - 83
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIAZOLAM; BENZODIAZEPINES; EFFICACY; DIAZEPAM; AGE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
L.Y. Jin e C.E. Lau, "DETERMINATION OF ALPRAZOLAM AND ITS MAJOR METABOLITES IN SERUM MICROSAMPLES BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND ITS APPLICATION TO PHARMACOKINETICS IN RATS", Journal of chromatography B. Biomedical applications, 654(1), 1994, pp. 77-83

Abstract

A high-performance liquid chromatographic method using a single-solvent extraction step is described for quantitating alprazolam and its metabolites in rat serum microsamples (50 mul). The separation used a 2-mm I.D. reversed-phase Ultrasphere C18 column with a mobile phase of methanol-acetonitrile-sodium acetate buffer. By decreasing the methanolcontent in the mobile phase, triazolam and its metabolites can be extracted and separated using the same method. The detection limit was 5 ng/ml for all the compounds using an ultraviolet detector at 230 nm. The method showed the effect of aging on alprazolam pharmacokinetics following 0.8 mg/kg intravenous bolus alprazolam administration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/05/20 alle ore 14:15:09