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Titolo:
EFFECTS OF PERIPHERALLY ADMINISTERED CORTICOTROPIN-RELEASING FACTOR (CRF) AND A CRF ANTAGONIST - DOES PERIPHERAL CRF ACTIVITY MEDIATE BEHAVIOR OF GUINEA-PIG PUPS DURING ISOLATION
Autore:
HENNESSY MB; LONG SJ; NIGH CK; WILLIAMS MT; NOLAN DJ;
Indirizzi:
WRIGHT STATE UNIV,DEPT PSYCHOL DAYTON OH 45435 MIAMI VALLEY HOSP,CLIN RES CTR DAYTON OH 45409
Titolo Testata:
Behavioral neuroscience
fascicolo: 6, volume: 109, anno: 1995,
pagine: 1137 - 1145
SICI:
0735-7044(1995)109:6<1137:EOPACF>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-HELICAL CRF; MATERNAL SEPARATION; BLOOD-PRESSURE; BETA-ENDORPHIN; OVINE CRF; STRESS; SECRETION; HORMONE; VOCALIZATIONS; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
M.B. Hennessy et al., "EFFECTS OF PERIPHERALLY ADMINISTERED CORTICOTROPIN-RELEASING FACTOR (CRF) AND A CRF ANTAGONIST - DOES PERIPHERAL CRF ACTIVITY MEDIATE BEHAVIOR OF GUINEA-PIG PUPS DURING ISOLATION", Behavioral neuroscience, 109(6), 1995, pp. 1137-1145

Abstract

Guinea pig pups vocalized and ambulated when first isolated in a testcage; at 1 and 24 hr, levels of these behaviors had waned, and pups frequently exhibited a crouched stance, eye-closing, and piloerection. Injection (SC) of corticotropin-releasing factor (CRF) prior to isolation diminished the initial vocalization and locomotor responses and induced pups to exhibit the crouched stance, eye-closing, and piloerection at the beginning of the isolation period. Pretreatment with a CRF-receptor antagonist reversed the behavioral effects of CRF. CRF had no effect on blood pressure. Thus, SC CRF produced the same behavioral profile as seen with the passage of time in untreated isolated pups. Thebehavioral effects appeared to be CRF-receptor-mediated events and were not secondary to hypotension. These results support the hypothesis that during prolonged isolation, high or sustained peripheral CRF activity modulates behavior.

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Documento generato il 29/02/20 alle ore 15:09:27