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Titolo:
PYRUVATE INFUSIONS INTO THE SEPTAL AREA ATTENUATE SPONTANEOUS-ALTERNATION IMPAIRMENTS INDUCED BY INTRASEPTAL MORPHINE INJECTIONS
Autore:
RAGOZZINO ME; HELLEMS K; LENNARTZ RC; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,DEPT PSYCHOL CHARLOTTESVILLE VA 22903
Titolo Testata:
Behavioral neuroscience
fascicolo: 6, volume: 109, anno: 1995,
pagine: 1074 - 1080
SICI:
0735-7044(1995)109:6<1074:PIITSA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACETYLCHOLINE SYNTHESIS; LOCOMOTOR-ACTIVITY; GLUCOSE; MEMORY; MICE; RAT; ENHANCEMENT; PERFORMANCE; BRAIN; ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Ragozzino et al., "PYRUVATE INFUSIONS INTO THE SEPTAL AREA ATTENUATE SPONTANEOUS-ALTERNATION IMPAIRMENTS INDUCED BY INTRASEPTAL MORPHINE INJECTIONS", Behavioral neuroscience, 109(6), 1995, pp. 1074-1080

Abstract

Glucose infusions into the medial septal area attenuate memory impairments produced by concurrent intraseptal morphine injections. One possible explanation fur these effects of glucose on memory is that the treatment modulates regional energy metabolism. As a test of this hypothesis, the present experiment determined whether intrasepral pyruvate injections could attenuate a spontaneous alternation impairment seen after intraseptal morphine injections. Intraseptal injections of morphine (4.0 nmol) 30 min prior to testing produced spontaneous alternation scores significantly Lower than those in control groups. Morphine injections near. but outside, the septal region did not impair spontaneousalternation performance. The morphine-induced impairment was similarly reversed by coadministration of either glucose (18 nmol) or pyruvate(18 nmol) into the septum. These findings suggest that glucose may act through the tricarboxylic acid cycle by increasing the availability of ATP, augmenting the synthesis of certain neurotransmitters, or both.

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Documento generato il 13/07/20 alle ore 17:42:50