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Titolo:
GLUTAMATE N-METHYL-D-ASPARTATE (NMDA) AND NON-NMDA RECEPTOR ANTAGONISTS ADMINISTERED INTO THE BRAIN-STEM DEPRESS THE RENAL SYMPATHETIC REFLEX DISCHARGES EVOKED BY SINGLE SHOCK OF SOMATIC AFFERENTS IN ANESTHETIZED RATS
Autore:
NAGATA O; LI WM; SATO A;
Indirizzi:
TOKYO METROPOLITAN INST GERONTOL,DEPT AUTONOM NERVOUS SYST,ITABASHI KU,35-2 SAKAECHO TOKYO 173 JAPAN TOKYO METROPOLITAN INST GERONTOL,DEPT AUTONOM NERVOUS SYST,ITABASHI KU TOKYO 173 JAPAN TOKYO METROPOLITAN NEUROL HOSP,DEPT ANESTHESIA TOKYO JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 201, anno: 1995,
pagine: 111 - 114
SICI:
0304-3940(1995)201:2<111:GN(ANR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURONS;
Keywords:
RENAL SYMPATHETIC NERVE; SOMATIC AFFERENT; SOMATOSYMPATHETIC REFLEX; GLUTAMATE RECEPTORS; N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST; NON-NMDA RECEPTOR ANTAGONIST; ANESTHETIZED RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
O. Nagata et al., "GLUTAMATE N-METHYL-D-ASPARTATE (NMDA) AND NON-NMDA RECEPTOR ANTAGONISTS ADMINISTERED INTO THE BRAIN-STEM DEPRESS THE RENAL SYMPATHETIC REFLEX DISCHARGES EVOKED BY SINGLE SHOCK OF SOMATIC AFFERENTS IN ANESTHETIZED RATS", Neuroscience letters, 201(2), 1995, pp. 111-114

Abstract

The involvement of glutamate receptors in the central transmission ofsomatosympathetic reflexes was studied by examining, in anesthetized rats, the effects of MK-801, an N-methyl-D-aspartate (NMDA) receptor antagonist, and CNQX, a non-NMDA receptor antagonist, on two reflex components, the A- and C-reflexes evoked in the left sympathetic renal nerve by a single shock to the left tibial nerve. The A-reflex elicited by myelinated A fiber stimulation and the C-reflex elicited by unmyelinated C fiber stimulation were depressed, in a dose-dependent manner, following administration of either MK-801 or CNQX into the cisterna magna (i.c.m.). Intrathecal (i.t.) administration of MK-801 did not haveany effect on either A- or C-reflexes, while i.t. administration of CNQX had a slight effect on the A-reflex (significantly on the A-reflexonly when treated with the highest dose of 100 ng) and the C-reflex. These results indicate that both NMDA and non-NMDA receptors, stimulated by glutamate released possibly as a neurotransmitter, are involved in the central transmission pathways of somatosympathetic reflexes at the level of the brain stem, but not the spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:42:24