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Titolo:
PATCH-CLAMP ANALYSIS OF SYNAPTIC TRANSMISSION TO CEREBELLAR PURKINJE-CELLS OF PRION PROTEIN KNOCKOUT MICE
Autore:
HERMS JW; KRETZSCHMAR HA; TITZ S; KELLER BU;
Indirizzi:
UNIV GOTTINGEN,DEPT NEUROPATHOL,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT NEUROPATHOL D-37075 GOTTINGEN GERMANY UNIV GOTTINGEN,CTR PHYSIOL & PATHOPHYSIOL D-37073 GOTTINGEN GERMANY
Titolo Testata:
European journal of neuroscience
fascicolo: 12, volume: 7, anno: 1995,
pagine: 2508 - 2512
SICI:
0953-816X(1995)7:12<2508:PAOSTT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT HIPPOCAMPAL SLICES; CENTRAL NERVOUS-SYSTEM; SCRAPIE PRION; CURRENTS; BRAIN; MEMBRANE; SUBUNITS; NEURONS;
Keywords:
CREUTZFELDT-JAKOB DISEASE; CEREBELLUM; INHIBITORY POSTSYNAPTIC CURRENTS; EXCITATORY POSTSYNAPTIC CURRENTS; THIN SLICE PREPARATIONS;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
J.W. Herms et al., "PATCH-CLAMP ANALYSIS OF SYNAPTIC TRANSMISSION TO CEREBELLAR PURKINJE-CELLS OF PRION PROTEIN KNOCKOUT MICE", European journal of neuroscience, 7(12), 1995, pp. 2508-2512

Abstract

The prion protein (PrP) plays a pivotal role in transmissible spongiform encephalopathies such as Creutzfeldt-Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals, Previous experiments have suggested that the normal cellular prion protein (PrPC) isinvolved in synaptic function in the hippocampus. Here, we utilized the controlled recording conditions of the patch-clamp technique to investigate the synaptic function of prion protein in cerebellar Purkinjecells. By performing whole-cell and outside-out patch-clamp experiments in thin slices, we investigated synaptic transmission in prion protein knockout mice (PrP-null) and control animals, In PrP-null mice, the kinetics of GABA- and glutamate receptor-mediated currents showed nosignificant deviation from those in control animals, In contrast to previous results in hippocampal neurons, our findings support the view that synaptic transmission is unimpaired in prion protein-deficient mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 18:15:24