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Titolo:
A METHOD TO STUDY CHANGES IN EYE RELATED COLUMNS IN THE VISUAL-CORTEXOF KITTENS DURING AND FOLLOWING EARLY PERIODS OF MONOCULAR DEPRIVATION
Autore:
MITCHELL DE; BEAVER CJ; RITCHIE PJ;
Indirizzi:
DALHOUSIE UNIV,DEPT PSYCHOL HALIFAX NS B3H 4J1 CANADA
Titolo Testata:
Canadian journal of physiology and pharmacology
fascicolo: 9, volume: 73, anno: 1995,
pagine: 1352 - 1363
SICI:
0008-4212(1995)73:9<1352:AMTSCI>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
OCULAR DOMINANCE COLUMNS; EARLY GENE-EXPRESSION; C-FOS PROTEIN; REVERSE OCCLUSION; DEPRIVED KITTENS; POSTNATAL-DEVELOPMENT; ORIENTATION COLUMNS; SENSITIVE PERIOD; NERVOUS-SYSTEM; RECOVERY;
Keywords:
DEVELOPMENT; VISION; VISUAL CORTEX; AMBLYOPIA; DEPRIVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
D.E. Mitchell et al., "A METHOD TO STUDY CHANGES IN EYE RELATED COLUMNS IN THE VISUAL-CORTEXOF KITTENS DURING AND FOLLOWING EARLY PERIODS OF MONOCULAR DEPRIVATION", Canadian journal of physiology and pharmacology, 73(9), 1995, pp. 1352-1363

Abstract

An immunohistochemical method that exploits the rapid light-evoked expression of Fos, the protein product of the immediate early gene, c-fos, to visualize eye-related columns in the visual cortex, has been used to provide preliminary data on the relative innervation of the cortex by the two eyes of monocularly deprived kittens and the speed of thechanges that occur afterward during reverse occlusion. In contrast toconventional anatomical techniques, the method allows both cellular resolution and documentation of the dimensions of eye-related columns through the depth of the cortex. In kittens monocularly deprived from near birth, Fos-immunoreactive neurones were observed in oval or circular patches, the size of which decreased as the duration of deprivationwas increased from 4 to 6 weeks. Following reverse occlusion at 5 weeks of age, the size of the patches increased rapidly so that after 4 days their area had approximately tripled. In addition to providing possible insights into the anatomical underpinnings of the puzzling behavioural effects that occur following termination of short periods of reverse occlusion, the method can be used to investigate the temporal order of the anatomical effects of monocular deprivation in different cortical layers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 22:32:22