Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
BRAIN 5-HT1C RECEPTORS AND ANTIDEPRESSANTS
Autore:
JENCK F; MOREAU JL; MUTEL V; MARTIN JR;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA,PRECLIN CENT NERVOUS SYST RESCH-4002 BASEL SWITZERLAND
Titolo Testata:
Progress in neuro-psychopharmacology & biological psychiatry
fascicolo: 3, volume: 18, anno: 1994,
pagine: 563 - 574
SICI:
0278-5846(1994)18:3<563:B5RAA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PENILE ERECTIONS; ANTI-DEPRESSANT DRUGS; CHOROID-PLEXUS; XENOPUS OOCYTES; BINDING-SITES; MESSENGER-RNA; RATS; ANTAGONISTS; CHLOROPHENYLPIPERAZINE;
Keywords:
ANTIDEPRESSANTS; RAT; SEROTONIN; 5-HT1C; 5-HT1A;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
F. Jenck et al., "BRAIN 5-HT1C RECEPTORS AND ANTIDEPRESSANTS", Progress in neuro-psychopharmacology & biological psychiatry, 18(3), 1994, pp. 563-574

Abstract

1. A variety of antidepressants of different chemical classes were tested for their in vivo and in vitro activity at 5-HT1C receptors in the brain. 2. Conventional tricyclic antidepressants (imipramine, desipramine, maprotiline, clomipramine, trimipramine, amitriptyline, nortriptyline, doxepin, amoxapine, oxaprotiline) and two atypical antidepressants (mianserin and trazodone) were found to display affinity for 5-HT1C receptors in the nanomolar range. 3. Antidepressants of other chemical classes and mechanisms of action (serotonin uptake inhibitors: fluoxetine, citalopram, sertraline, fluvoxamine; noradrenaline - dopamineuptake inhibitors: nomifensine, bupropion, amineptine; or monoamine oxidase inhibitors: moclobemide, iproniazid) had affinities in the micromolar range for 5-HT1C receptors, except fluoxetine. 4. When tested in an in vivo functional model revealing agonistic or antagonistic properties at 5-HT1C receptors, all antidepressants displaying high affinity for this receptor type (except fluoxetine, clomipramine, trimipramine and oxaprotiline) were antagonists at 5-HT1C receptors. Antidepressants with lower 5-HT1C receptor affinity (except nomifensine) were inactive in this functional in vivo model. 5. Antagonism at brain 5-HT1C receptors is a component of the antiserotonergic properties of a number of established antidepressants, especially of the tricyclic class.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:28:54