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Titolo:
ON THE IMMUNOSTIMULATIVE AND IMMUNOSUPPRESSIVE CONFORMATION OF THYMOPENTIN ANALOGS
Autore:
SIEMION IZ; SZEWCZUK Z; KLUCZYK A; SLON JJ; WIECZOREK Z;
Indirizzi:
UNIV WROCLAW,INST CHEM,F JOLIOT CURIE 14 PL-50383 WROCLAW POLAND POLISH ACAD SCI,INST IMMUNOL & EXPTL THERAPY PL-53114 WROCLAW POLAND
Titolo Testata:
Polish Journal of Chemistry
fascicolo: 12, volume: 69, anno: 1995,
pagine: 1669 - 1678
SICI:
0137-5083(1995)69:12<1669:OTIAIC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Keywords:
LACTOFERRIN; PEPTIDE IMMUNOSUPPRESSORS; THYMOPENTIN ANALOGS; THYMOPENTIN BIOLOGICALLY ACTIVE CONFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
I.Z. Siemion et al., "ON THE IMMUNOSTIMULATIVE AND IMMUNOSUPPRESSIVE CONFORMATION OF THYMOPENTIN ANALOGS", Polish Journal of Chemistry, 69(12), 1995, pp. 1669-1678

Abstract

A series of structural analogues of lactoferrin immunosuppressive pentapeptide I (Arg-Lys-Pro-Val-Asp) were investigated for their immunomodulatory activity. The series consisted of the following compounds: Arg-Lys-Pro-Val-D-Asp (II), Arg-Lys-D-Pro-Val-Asp (III), Cys(Acm)-Arg-Lys-Pro-Val-Asp-Cys(Acm) (IV), Cys(Acm)-Arg-Lys-D-Pro-Val-Asp-Cys(Acm) (V) and two cyclic peptides VI and VII: H-Cys-Arg-Lys-Pro-Val-Asp-Cys-OII (VI) II-Cys-Arg-Lys-D-Pro-Val-Asp-Cys-OH (VII) We found that all these compounds demonstrate the immunosuppressive activity of diverse range regarding the both: humoral and cellular immune response. Using the conformation of I resulted from X-ray data as tile model ''immunosuppressive'' conformation we compared it with the ''immunostimulative'' conformation proposed for thymopentin (TPS) [1]. The tolerance of the bioactive conformation of I to the configurational change on tile central Pro residue was also investigated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 15:03:12