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Titolo:
ANTIPARKINSONIAN ACTION OF MK-801 ON THE RESERPINE-INDUCED RIGIDITY -A MECHANOMYOGRAPHIC ANALYSIS
Autore:
OSSOWSKA K; LORENCKOCI E; WOLFARTH S;
Indirizzi:
POLISH ACAD SCI,INST PHARMACOL,DEPT NEUROPSYCHOPHARMACOL,12 SMETNA STPL-31343 KRAKOW POLAND
Titolo Testata:
Journal of neural transmission. Parkinson's disease and dementia section
fascicolo: 2, volume: 7, anno: 1994,
pagine: 143 - 152
SICI:
0936-3076(1994)7:2<143:AAOMOT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONIST DIZOCILPINE MK-801; MONOAMINE-DEPLETED MICE; ASPARTATE NMDA RECEPTOR; EXCITATORY AMINO-ACIDS; PARKINSONS-DISEASE; L-DOPA; EXPERIMENTAL CATALEPSY; NUCLEUS-ACCUMBENS; BASAL GANGLIA; MUSCLE TONE;
Keywords:
PARKINSONS DISEASE; RESERPINE; MUSCLE RIGIDITY; NMDA RECEPTORS; MK-801;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
K. Ossowska et al., "ANTIPARKINSONIAN ACTION OF MK-801 ON THE RESERPINE-INDUCED RIGIDITY -A MECHANOMYOGRAPHIC ANALYSIS", Journal of neural transmission. Parkinson's disease and dementia section, 7(2), 1994, pp. 143-152

Abstract

MK-801, a non-competitive antagonist of NMDA receptors, is known to exhibit a beneficial action in many animal models of Parkinson's disease. The aim of this study was to examine the influence of MK-801 on thereserpine-induced muscle rigidity. The rigidity was estimated by a direct mechanomyographic method. This method consists in successive bending and straightening of a rat's hind foot in the ankle joint and measuring the resistance of the foot to passive movements. Reserpine in doses of 5-10 mg/ kg ip, given alone or in combination with alpha-methyl-p-tyrosine (alpha MT, 250 mg/kg ip), induced rigidity. The strongest muscle rigidity was induced by 10 mg/kg of reserpine 1 hour after administration. MK-801 (0.32-1.28 mg/kg sc) injected 70 min after reserpine (10 mg/kg ip) decreased the rigidity induced by the latter compound. Similarly, MK-801 (1.28 mg/kg sc), administered 27h40' after joint treatment with reserpine (10 mg/kg ip) and alpha MT (250 mg/kg ip), strongly inhibited the reserpine-induced muscle rigidity. The obtained results show that the glutamatergic hyperactivity plays a significant role in the reserpine-induced rigidity. As the reserpine-induced motor disturbances are commonly accepted to be an animal model of parkinsoniansymptoms, it may be assumed that the NMDA receptor blocking componentmay contribute substantially to the therapeutic action of antiparkinsonian drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:10:53