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Titolo:
KAPOSIS-SARCOMA, VASCULAR-PERMEABILITY, AND SCIENTIFIC INTEGRITY
Autore:
WITTE MH; BORGS P; WAY DL; BERNAS M; RAMIREZ G; WITTE CL;
Indirizzi:
UNIV ARIZONA,COLL MED,DEPT SURG,1501 N CAMPBELL AVE TUCSON AZ 85724
Titolo Testata:
JAMA, the journal of the American Medical Association
fascicolo: 22, volume: 271, anno: 1994,
pagine: 1769 - 1771
SICI:
0098-7484(1994)271:22<1769:KVASI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
2
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Witte et al., "KAPOSIS-SARCOMA, VASCULAR-PERMEABILITY, AND SCIENTIFIC INTEGRITY", JAMA, the journal of the American Medical Association, 271(22), 1994, pp. 1769-1771

Abstract

On March 13, 1992, Nakamura et al published an article in the journalScience reporting that sulfated polysaccharide peptidoglycan (SP-PG) inhibited the growth and vascular hyperpermeability characteristics ofKaposi's sarcoma-related cells and lesions in nude mice. While examining their key composite Fig 3, A through E, and related Table 2, we were surprised by several photographic features and other irregularitiesin the figures, which we explored further through a series of experiments. We were unable to confirm some of the pivotal findings. We communicated our concerns to Science but our letter was rejected. After submission of additional analysis, the matter was reopened by Science, but again our correspondence was rejected. Despite extensive review, thesalient points raised in our initial correspondence remain unansweredor only tangentially addressed. The original conclusions by Nakamura et al are still not only highly dubious, but the validity of the peer review process and self-correcting nature of scientific inquiry are also called into question.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 19:01:46