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Titolo:
NEW DIBENZAZEPINE DERIVATIVES WITH DISINHIBITORY AND OR ANTIDEPRESSANT POTENTIAL - NEUROCHEMICAL AND BEHAVIORAL-STUDY IN THE OPEN-FIELD ANDFORCED SWIMMING TESTS/
Autore:
BRUHWYLER J; LIEGEOIS JF; LEJEUNE C; ROGISTER F; DELARGE J; GECZY J;
Indirizzi:
THERABEL RES SA,CHAUSSEE ALSEMBERG 1001 B-1180 BRUSSELS BELGIUM UNIV LIEGE,INST PHARM B-4000 LIEGE BELGIUM UNIV NAMUR,FAC MED B-5000 NAMUR BELGIUM
Titolo Testata:
Behavioural pharmacology
fascicolo: 8, volume: 6, anno: 1995,
pagine: 830 - 838
SICI:
0955-8810(1995)6:8<830:NDDWDA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATYPICAL ANTIPSYCHOTIC-DRUGS; ANTI-ANXIETY AGENTS; PHARMACOLOGICAL EVALUATION; SQUIRREL-MONKEYS; CLOZAPINE; CHLORDIAZEPOXIDE; MODEL; RATS; BINDING; MICE;
Keywords:
ANTIDEPRESSANT; ATYPICAL NEUROLEPTIC; CLOZAPINE DERIVATIVES; DISINHIBITION; DOPAMINE; FORCED SWIMMING TEST; RAT; MOUSE; OPEN-FIELD TEST; SEROTONIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
J. Bruhwyler et al., "NEW DIBENZAZEPINE DERIVATIVES WITH DISINHIBITORY AND OR ANTIDEPRESSANT POTENTIAL - NEUROCHEMICAL AND BEHAVIORAL-STUDY IN THE OPEN-FIELD ANDFORCED SWIMMING TESTS/", Behavioural pharmacology, 6(8), 1995, pp. 830-838

Abstract

Original bioisosteric analogues of clozapine were evaluated for potential disinhibitory and/or antidepressant effects using the open-field test in the rat and Porsolt's forced swimming test in the mouse. Attempts to relate the behavioural results to the binding affinities for dopamine (D1, D2), serotonin (5-HT2) and muscarinic (M) receptors were also undertaken. In the open-field test, two main profiles were observed. The first profile corresponded to disinhibitory molecules resembling diazepam and ritanserin. The second profile corresponded to antipsychotic compounds resembling either typical (haloperidol, clothiapine) or atypical (clozapine) neuroleptics. The results obtained in the forced swimming test confirmed the neuroleptic-like activity of the second group of compounds, while two compounds of the first group (JL 3 and JL 26) showed an antidepressant-like activity, JL 3 being as active as imipramine. While it was not possible to relate the first profile to any binding interaction, a relation could be established among the second group of compounds between the typical or atypical antipsychotic behavioural profile and the 5-HT2/D2 ratio.

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Documento generato il 04/04/20 alle ore 07:41:41