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Titolo:
MOLECULAR-CLONING OF A NOVEL SERINE THREONINE KINASE, MRK, POSSIBLY INVOLVED IN CARDIAC DEVELOPMENT/
Autore:
ABE S; YAGI T; ISHIYAMA S; HIROE M; MARUMO F; IKAWA Y;
Indirizzi:
RIKEN,INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR,3-1-1 KOYADAI TSUKUBAIBARAKI 305 JAPAN RIKEN,INST PHYS & CHEM RES,TSUKUBA LIFE SCI CTR TSUKUBA IBARAKI 305 JAPAN TOKYO MED & DENT UNIV,SCH MED,DEPT INTERNAL MED 2,BUNKYO KU TOKYO 113JAPAN TOKYO MED & DENT UNIV,SCH MED,DEPT BIOCHEM,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Oncogene
fascicolo: 11, volume: 11, anno: 1995,
pagine: 2187 - 2195
SICI:
0950-9232(1995)11:11<2187:MOANST>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBROBLAST GROWTH-FACTOR; POLYMERASE CHAIN-REACTION; PROTEIN-KINASE; PHOSPHORYLATION SITES; REGULATORY PHOSPHORYLATION; SACCHAROMYCES-CEREVISIAE; ENDOTHELIAL-CELLS; PHORBOL ESTERS; P34CDC2 KINASE; MAP KINASE;
Keywords:
SERINE/THREONINE PROTEIN KINASE; CARDIAC DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
S. Abe et al., "MOLECULAR-CLONING OF A NOVEL SERINE THREONINE KINASE, MRK, POSSIBLY INVOLVED IN CARDIAC DEVELOPMENT/", Oncogene, 11(11), 1995, pp. 2187-2195

Abstract

We have isolated a novel member of putative serine/threonine kinase from a rat heart cDNA library using polymerase chain reaction methods, The novel kinase is transcribed as 2.6 kb mRNA encoding for a protein of 629 amino acids with the long C-terminal non-catalytic portion, Amino acids analysis revealed that the N-terminal catalytic domain is 87%identical to the male-germ cell associated kinase (MAK), a cdc2-related serine/threonine kinase found to promote meiosis during spermatogenesis, Therefore, we designated this novel kinase as the MAK-related kinase (MRK), MRK protein, with a molecular weight of 66 kD, was shown to phosphorylate itself and the exogenous substrates, histone H1 and myelin basic protein, In addition, phosphoamino acid analysis confirmed the serine/threonine-specific protein kinase activity of MRK, AlthoughMRK was ubiquitous in adult rat tissues, the expression of MRK protein in embryos was restricted primarily to embryonic myocardium during early organogenesis, This finding suggests that MRK may be a participant in cardiac development.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 23:11:01