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Titolo:
NEUTROPHIL INHIBITORY FACTOR IS NEUROPROTECTIVE AFTER FOCAL ISCHEMIA IN RATS
Autore:
JIANG N; MOYLE M; SOULE HR; ROTE WE; CHOPP M;
Indirizzi:
HENRY FORD HOSP,2799 W GRAND BLVD DETROIT MI 48202 HENRY FORD HLTH SCI CTR,DEPT NEUROL DETROIT MI 00000 CORVAS INT INC SAN DIEGO CA 00000 OAKLAND UNIV,DEPT PHYS ROCHESTER MI 00000
Titolo Testata:
Annals of neurology
fascicolo: 6, volume: 38, anno: 1995,
pagine: 935 - 942
SICI:
0364-5134(1995)38:6<935:NIFINA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ARTERY OCCLUSION; MONOCLONAL-ANTIBODY; MYOCARDIAL INJURY; POLYMORPHONUCLEAR LEUKOCYTES; REPERFUSION INJURY; ADHESION MOLECULE; REDUCTION; CELL; GRANULOCYTES; MONOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
N. Jiang et al., "NEUTROPHIL INHIBITORY FACTOR IS NEUROPROTECTIVE AFTER FOCAL ISCHEMIA IN RATS", Annals of neurology, 38(6), 1995, pp. 935-942

Abstract

We tested the neuroprotective potential of neutrophil inhibitory factor (rNIF), a novel 41-kd recombinant glycoprotein derived from a hookworm, in a model of focal cerebral ischemia in the rat. Male Wistar rats were assigned to treatment with rNIF and vehicle. Middle cerebral artery occlusion (MCAO) for 2 hours was induced by insertion of an intraluminal suture. Infusion of the drug was initiated at the onset of reperfusion. Infarct volume was determined 48 hours after reperfusion. Neutrophils were measured within the ischemic tissue by myeloperoxidase (MPG) staining. Treatment with rNIF resulted in a 48% reduction in cerebral infarction compared with control animals (P < 0.01). Neutrophil accumulation in the ischemic brains of rNIF-treated rats was reduced significantly (p < 0.01) compared with control animals. The number of neutrophils within the infaraed tissue correlated positively with the size of the area of infarction (p < 0.001, r = 0.6) within representative cerebral coronal sections. We demonstrated a significant neuroprotective effect of rNIF with continuous treatment for 48 hours following 2 hours of MCAO. The neuroprotective effect was correlated with a reduced number of neutrophils within the ischemic tissue. These results demonstrate potential therapeutic properties of rNIF in the management of stroke.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 00:54:42