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Titolo:
IN-VITRO EFFECTS OF BICARBONATE-BUFFERED VERSUS LACTATE-BUFFERED CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS FLUIDS ON PERITONEAL MACROPHAGE FUNCTION
Autore:
FISCHER FP; SCHENK U; KIEFER T; HUBEL E; THOMAS S; YATZIDIS H; METTANG T; KUHLMANN U;
Indirizzi:
ROBERT BOSCH KRANKENHAUS,DEPT INTERNAL MED,DIV NEPHROL,AUERBACHSTR 110 D-70376 STUTTGART GERMANY ROBERT BOSCH KRANKENHAUS,DEPT INTERNAL MED,DIV NEPHROL D-70376 STUTTGART GERMANY UNIV ATHENS,ARETAIEON HOSP,SCH MED,CTR NEPHROL ATHENS GREECE
Titolo Testata:
American journal of kidney diseases
fascicolo: 6, volume: 26, anno: 1995,
pagine: 924 - 933
SICI:
0272-6386(1995)26:6<924:IEOBVL>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN POLYMORPHONUCLEAR LEUKOCYTES; DEPENDENT CHEMI-LUMINESCENCE; SUPEROXIDE PRODUCTION; DEFENSE-MECHANISMS; PHAGOCYTE FUNCTION; INHIBITION; MONOCYTES; INVITRO; RELEASE;
Keywords:
PERITONEAL DIALYSIS; CONTINUOUS AMBULATORY PERITONEAL DIALYSIS; PERITONEAL MACROPHAGE; PERITONEAL DIALYSIS FLUIDS; BICARBONATE; LACTATE; LEUKOCYTE FUNCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
F.P. Fischer et al., "IN-VITRO EFFECTS OF BICARBONATE-BUFFERED VERSUS LACTATE-BUFFERED CONTINUOUS AMBULATORY PERITONEAL-DIALYSIS FLUIDS ON PERITONEAL MACROPHAGE FUNCTION", American journal of kidney diseases, 26(6), 1995, pp. 924-933

Abstract

At present, lactate is the most commonly used buffer in peritoneal dialysis fluids (PDFs), The high lactate concentration in combination with low original pH was demonstrated to suppress phagocytic function, We evaluated the in vitro effects of a newly formulated bicarbonate;buffered PDF containing glycylglycine (BiGG15 and BiGG40; Pierre Fabre Medicament, Castres, France) on peritoneal macrophage (PM0) function, and compared them with those of equiosmolar lactate-buffered PDF (1.5% and 4.25% glucose; pH 5.4 and pH 7.4) and control buffer, Peritoneal macrophages were isolated from the effluents of 10 continuous ambulatoryperitoneal dialysis patients and tested for luminol- and lucigenin-enhanced chemiluminescence, superoxide (O-2(-)) generation measured by cytochrome c reduction, killing capacity, and phagocytosis after incubation in the PDF used, Exposure of PM0 to lactate-buffered PDF with an original pH of 5.4 resulted in a significant suppression of all PM0 functions measured, compared with bicarbonate- and lactate-buffered PDFswith a pH of 7.4, At physiological pH (7.4), chemiluminescence generation of PM0 exposed to BiGG15/40 was significantly higher compared with the corresponding equiosmolar lactate-buffered PDF (1,992 +/- 858 x 10(3) cpm/10(4) cells v 856 +/- 398 x 10(3) cpm/10(4) cells; P < 0.004), O-2(-) generation, killing capacity, and phagocytosis were not significantly different after PM0 exposure to bicarbonate compared with exposure to lactate-buffered PDF with a neutral pH, Irrespective of the buffer used, high-osmolality PDFs suppressed PM0 function significantly more than low-osmolar PDFs, In conclusion, bicarbonate-buffered PDFsare less detrimental to PM0) function than lactate-containing PDFs; these preliminary in vitro results need to be confirmed in vivo. (C) 1995 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 10:41:03