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Titolo:
HUMAN SEMINAL PLASMA PREVENTS SPERM FROM BECOMING ACROSOMALLY RESPONSIVE TO THE AGONIST, PROGESTERONE - CHOLESTEROL IS THE MAJOR INHIBITOR
Autore:
CROSS NL;
Indirizzi:
OKLAHOMA STATE UNIV,DEPT PHYSIOL SCI STILLWATER OK 74074
Titolo Testata:
Biology of reproduction
fascicolo: 1, volume: 54, anno: 1996,
pagine: 138 - 145
SICI:
0006-3363(1996)54:1<138:HSPPSF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-SPERMATOZOA; FERTILIZING-CAPACITY; INVITRO CAPACITATION; GUINEA-PIG; INDUCTION; RABBIT; FLUID; COMPONENTS; EFFLUX; PROSTASOMES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
N.L. Cross, "HUMAN SEMINAL PLASMA PREVENTS SPERM FROM BECOMING ACROSOMALLY RESPONSIVE TO THE AGONIST, PROGESTERONE - CHOLESTEROL IS THE MAJOR INHIBITOR", Biology of reproduction, 54(1), 1996, pp. 138-145

Abstract

Seminal plasma inhibits human sperm from developing the ability to undergo the acrosome reaction. The inhibitory activity was identified asthat of cholesterol on the basis of its solubility in organic solvents, its chromatographic behavior (adsorption, thin-layer, and gas chromatography), and its mass spectrum. Contrary to findings in other reports, no evidence for inhibitory proteins or peptides was found, and spermine was not an effective inhibitor. The inhibitory activity of untreated seminal plasma from individual ejaculates was highly correlated with the cholesterol content of the ejaculates (r = 0.96), suggesting that the amount of cholesterol determines the inhibitory activity of unfractionated seminal plasma. The inhibitory activity of unfractionatedseminal plasma was significantly less, relative to the cholesterol content, than the activity of pure cholesterol, which is consistent withthe idea that there are components in seminal plasma that partially counter the effect of cholesterol by promoting the development of acrosomal responsiveness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:14:58