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Titolo:
THE EMERGING ROLE OF CYTOCHROME-P450 3A IN PSYCHOPHARMACOLOGY
Autore:
KETTER TA; FLOCKHART DA; POST RM; DENICOFF K; PAZZAGLIA PJ; MARANGELL LB; GEORGE MS; CALLAHAN AM;
Indirizzi:
NIMH,BIOL PSYCHIAT BRANCH,3 W CLIN RES UNIT,BLDG 10,ROOM 3N212,9000 ROCKVIL BETHESDA MD 20892 GEORGETOWN UNIV,MED CTR,DEPT MED,DIV CLIN PHARMACOL WASHINGTON DC 20007 GEORGETOWN UNIV,MED CTR,DEPT PHARMACOL WASHINGTON DC 20007
Titolo Testata:
Journal of clinical psychopharmacology
fascicolo: 6, volume: 15, anno: 1995,
pagine: 387 - 398
SICI:
0271-0749(1995)15:6<387:TEROC3>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-LIVER-MICROSOMES; PHARMACOKINETIC DRUG-INTERACTIONS; SEROTONIN REUPTAKE INHIBITORS; CALCIUM-CHANNEL BLOCKERS; HUMAN CELL-LINE; N-DEMETHYLATION; EPILEPTIC PATIENTS; HUMAN HEPATOCYTES; OXIDATION POLYMORPHISM; NIFEDIPINE OXIDASE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
173
Recensione:
Indirizzi per estratti:
Citazione:
T.A. Ketter et al., "THE EMERGING ROLE OF CYTOCHROME-P450 3A IN PSYCHOPHARMACOLOGY", Journal of clinical psychopharmacology, 15(6), 1995, pp. 387-398

Abstract

Recent advances in molecular pharmacology, have allowed the characterization of the specific isoforms that mediate the metabolism of various medications. This information can be integrated with older clinical observations to begin to develop specific mechanistic and predictive models of psychotropic drug interactions. The polymorphic cytochrome P450 2D6 has gained much attention, because competition for this isoformis responsible for serotonin reuptake inhibitor-induced increases in tricyclic antidepressant concentrations in plasma. However, the cytochrome P450 3A subfamily and the 3A3 and 3A4 isoforms (CYP3A3/4) in particular are becoming increasingly important in psychopharmacology as a result of their central involvement in the metabolism of a wide range of steroids and medications, including antidepressants, benzodiazepines, calcium channel blockers, and carbamazepine. The inhibition of CYP3A3/4 by medications such as certain newer antidepressants, calcium channel blockers, and antibiotics can increase the concentrations of CYP3A3/4 substrates, yielding toxicity. The induction of CYP3A3/4 by medications such as carbamazepine can decrease the concentrations of CYP3A3/4 substrates, yielding inefficiency. Thus, knowledge of the substrates, inhibitors, and inducers of CYP3A3/4 and other cytochrome P450 isoforms may help clinicians to anticipate and avoid pharmacokinetic drug interactions and improve rational prescribing practices.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 04:24:27