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Titolo:
STRIATAL DOPAMINE TRANSPORTER IMAGING IN NONHUMAN-PRIMATES WITH IODINE-123-IPT SPECT
Autore:
MALISON RT; VESSOTSKIE JM; KUNG MP; MCELGIN W; ROMANIELLO G; KIM HJ; GOODMAN MM; KUNG HF;
Indirizzi:
UNIV PENN,SCH MED,DEPT RADIOL,3700 MARKET ST,ROOM 305 PHILADELPHIA PA19104 YALE UNIV,SCH MED,DEPT PSYCHIAT NEW HAVEN CT 06519 UNIV TENNESSEE,DEPT RADIOL KNOXVILLE TN 37996
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 12, volume: 36, anno: 1995,
pagine: 2290 - 2297
SICI:
0161-5505(1995)36:12<2290:SDTIIN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; NOREPINEPHRINE UPTAKE SITES; H-3 PAROXETINE BINDING; SEROTONIN UPTAKE SITES; HUMAN-BRAIN; COCAINE BINDING; REUPTAKE SITES; I-125 RTI-55; RAT-BRAIN; PARKINSONS-DISEASE;
Keywords:
IODINE-123-IPT; DOPAMINE TRANSPORTERS; SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
R.T. Malison et al., "STRIATAL DOPAMINE TRANSPORTER IMAGING IN NONHUMAN-PRIMATES WITH IODINE-123-IPT SPECT", The Journal of nuclear medicine, 36(12), 1995, pp. 2290-2297

Abstract

The regional distribution, kinetics and pharmacological specificity of a new radioiodinated cocaine analog, N-((E)3-iodopropen-2-yl)-2 beta-carbomethoxy-3 beta-(4-chlorophenyl tropane ([I-123]IPT) were examined in brain SPECT studies (n = 20) of nonhuman primates. Methods: Radiolabeling and purification of the iododestannylated trialkyltin precursor yielded the tracer at greater than 90% radiochemical purity and high (>20,000 Ci/mmole) specific activity. Cynomologous monkeys were injected with 7.2 +/- 1.3 mCi (mean +/- s.d.) of the tracer, and serial 10-min images were acquired (total scan time = 177 +/- 22 min). Images were reconstructed as transaxial slices (2 mm) using restorative techniques (Wiener prefiltering). Results: Radioactivity concentrated quickly in striatal regions (time of peak = 25 +/- 13 min) and cleared gradually thereafter(8.8 +/- 4.6 %/hr). Striatal-to-cerebellar ratios of 2.6 +/- 1.5 (n = 19), 6.7 +/- 3.2 (n = 20), 15.1 +/- 10.7 (n = 10) and 22.8 +/- 11.0 (n = 9) were observed at the time of peak and at 1, 2 and3 hr p.i., respectively. In contrast, extrastriatal activity peaked earlier and at lower levels, cleared more rapidly and resembled cerebellar time-activity curves. Displacing doses of nonspecific antagonists of monoamine transporters (mazindol and beta-CIT) showed that 95% of specific [(131)]IPT binding was reversible, while selective antagonists(e.g., paroxetine, nisoxetine and GBR 12909) demonstrated that striatal activity was specifically associated with dopamine transporters. Conclusion: These results indicate that [123I]lPT is a useful radioligand for in vivo SPECT imaging of striatal dopamine transporters.

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Documento generato il 07/04/20 alle ore 22:56:42