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Titolo:
PET OF PERIPHERAL BENZODIAZEPINE BINDING-SITES IN THE MICROGLIOSIS OFALZHEIMERS-DISEASE
Autore:
GROOM GN; JUNCK L; FOSTER NL; FREY KA; KUHL DE;
Indirizzi:
UNIV MICHIGAN,CTR MED,DIV NUCL MED,1500 E MED CTR DR,B1 G412-0028 ANNARBOR MI 48109 UNIV MICHIGAN,CTR MED,DIV NUCL MED ANN ARBOR MI 48109 UNIV MICHIGAN,CTR MED,DEPT NEUROL ANN ARBOR MI 48109
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 12, volume: 36, anno: 1995,
pagine: 2207 - 2210
SICI:
0161-5505(1995)36:12<2207:POPBBI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-3 PK-11195; AUTORADIOGRAPHIC LOCALIZATION; FOCAL ISCHEMIA; HUMAN GLIOMAS; RECEPTORS; BRAIN; CORTEX; RAT; DEMENTIA; LIGANDS;
Keywords:
POSITRON EMISSION TOMOGRAPHY; ALZHEIMERS DISEASE; PERIPHERAL BENZODIAZEPINE BINDING SITE; MICROGLIOSIS; INFLAMMATION; PK-11195;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
G.N. Groom et al., "PET OF PERIPHERAL BENZODIAZEPINE BINDING-SITES IN THE MICROGLIOSIS OFALZHEIMERS-DISEASE", The Journal of nuclear medicine, 36(12), 1995, pp. 2207-2210

Abstract

Animal and human autoradiographic studies have shown increased in vitro binding of the peripheral benzodiazepine binding site antagonist PK11195 in areas of microgliosis, including the temporal association cortex of patients with Alzheimer's disease. To further elucidate the role of cellular inflammation and microgliosis in Alzheimer's disease during life, we used PET and [C-11]PK 11195, a peripheral benzodiazepinereceptor ligand known to bind avidly to microglia. Methods: Eight patients with a diagnosis of probable Alzheimer's disease underwent PET of the brain using [C-11]PK 11195 and, for comparison, with [F-18]FDG to determine cerebral glucose metabolism. Uptake of [C-11]PK 11195 in various brain regions was expressed relative to that in the cerebellum and compared to values determined in one normal elderly subject and inclinically and anatomically unaffected hemispheres of seven patients with small unliateral gliomas. Results: No increases in peripheral benzodiazepine binding were identified in patients with probable Alzheimer's disease, and binding was lowest in regions that were most hypometabolic. Conclusion: The peripheral benzodiazepine binding sites associated with microgliosis and cellular inflammation in Alzheimer's diseaseat postmortem are undetectable by PET using [C-11]PK 11195 in patients with mild-to-moderate dementia.

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Documento generato il 11/07/20 alle ore 13:22:45